Research ArticleNanomedicine

Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species

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Science Translational Medicine  21 Aug 2019:
Vol. 11, Issue 506, eaaw7736
DOI: 10.1126/scitranslmed.aaw7736

Particle production

Scale-up is a nontrivial part of translating a therapy from preclinical work in small animal models toward clinical utility. Binderup, Duivenvoorden, Fay, and colleagues previously developed simvastatin-loaded high-density lipoprotein (S-HDL) particles that inhibited macrophage proliferation in the blood vessel walls of mouse models of atherosclerosis. Here, they tested methods to produce large amounts of S-HDL needed for larger animal studies and imaging protocols to evaluate therapeutic efficacy. The scaled-up particles showed anti-inflammatory effects in the blood vessels of rabbit and porcine models of atherosclerosis, reducing vessel wall enlargement. This study highlights challenges encountered when scaling a nanoimmunotherapy for use in larger animal models and strategies to overcome these challenges.

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