Research ArticleNanomedicine

Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species

See allHide authors and affiliations

Science Translational Medicine  21 Aug 2019:
Vol. 11, Issue 506, eaaw7736
DOI: 10.1126/scitranslmed.aaw7736

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Particle production

Scale-up is a nontrivial part of translating a therapy from preclinical work in small animal models toward clinical utility. Binderup, Duivenvoorden, Fay, and colleagues previously developed simvastatin-loaded high-density lipoprotein (S-HDL) particles that inhibited macrophage proliferation in the blood vessel walls of mouse models of atherosclerosis. Here, they tested methods to produce large amounts of S-HDL needed for larger animal studies and imaging protocols to evaluate therapeutic efficacy. The scaled-up particles showed anti-inflammatory effects in the blood vessels of rabbit and porcine models of atherosclerosis, reducing vessel wall enlargement. This study highlights challenges encountered when scaling a nanoimmunotherapy for use in larger animal models and strategies to overcome these challenges.

View Full Text

Stay Connected to Science Translational Medicine