Research ArticleInflammation
Treating murine inflammatory diseases with an anti-erythrocyte antibody
- Andrew R. Crow1,2,3,*,
- View ORCID ProfileRick Kapur1,2,3,4,5,*,
- Sandra Koernig6,
- Ian K. Campbell6,
- View ORCID ProfileChao-Ching Jen2,3,
- View ORCID ProfilePatrick J. Mott2,3,
- Danielle Marjoram2,3,
- View ORCID ProfileRamsha Khan2,3,
- Michael Kim2,3,
- Jennifer Brasseit7,
- View ORCID ProfileYoelys Cruz-Leal1,2,3,
- View ORCID ProfileAlaa Amash2,3,
- Simrat Kahlon2,3,
- View ORCID ProfileIssaka Yougbare1,2,3,
- View ORCID ProfileHeyu Ni1,2,3,8,9,10,
- Adrian W. Zuercher7,
- View ORCID ProfileFabian Käsermann7,
- John W. Semple1,2,3,4,8,9,11 and
- View ORCID ProfileAlan H. Lazarus1,2,3,8,9,†
- 1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.
- 2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
- 3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
- 4Department of Hematology and Transfusion Medicine, Lund University, Lund 221 84, Sweden.
- 5Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, Netherlands.
- 6CSL Limited, Bio21 Institute, University of Melbourne, Parkville, Victoria 3010, Australia.
- 7CSL Behring, Research, CSL Biologics Research Center, Bern, Switzerland.
- 8Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
- 9Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
- 10Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
- 11Department of Pharmacology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
- ↵†Corresponding author. Email: lazarusa{at}smh.ca
↵* These authors contributed equally to this work as co-first authors.
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Science Translational Medicine 21 Aug 2019:
Vol. 11, Issue 506, eaau8217
DOI: 10.1126/scitranslmed.aau8217
Vol. 11, Issue 506, eaau8217
DOI: 10.1126/scitranslmed.aau8217
Andrew R. Crow
1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
Rick Kapur
1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
4Department of Hematology and Transfusion Medicine, Lund University, Lund 221 84, Sweden.
5Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, Netherlands.
Sandra Koernig
6CSL Limited, Bio21 Institute, University of Melbourne, Parkville, Victoria 3010, Australia.
Ian K. Campbell
6CSL Limited, Bio21 Institute, University of Melbourne, Parkville, Victoria 3010, Australia.
Chao-Ching Jen
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
Patrick J. Mott
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
Danielle Marjoram
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
Ramsha Khan
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
Michael Kim
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
Jennifer Brasseit
7CSL Behring, Research, CSL Biologics Research Center, Bern, Switzerland.
Yoelys Cruz-Leal
1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
Alaa Amash
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
Simrat Kahlon
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
Issaka Yougbare
1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
Heyu Ni
1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
8Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
9Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
10Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Adrian W. Zuercher
7CSL Behring, Research, CSL Biologics Research Center, Bern, Switzerland.
Fabian Käsermann
7CSL Behring, Research, CSL Biologics Research Center, Bern, Switzerland.
John W. Semple
1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
4Department of Hematology and Transfusion Medicine, Lund University, Lund 221 84, Sweden.
8Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
9Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
11Department of Pharmacology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Alan H. Lazarus
1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.
2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
8Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
9Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
