Treating murine inflammatory diseases with an anti-erythrocyte antibody

Andrew R. Crow; Rick Kapur; Sandra Koernig; Ian K. Campbell; Chao-Ching Jen; Patrick J. Mott; Danielle Marjoram; Ramsha Khan; Michael Kim; Jennifer Brasseit; Yoelys Cruz-Leal; Alaa Amash; Simrat Kahlon; Issaka Yougbare; Heyu Ni; Adrian W. Zuercher; Fabian Käsermann; John W. Semple; Alan H. Lazarus

doi:10.1126/scitranslmed.aau8217

Research ArticleInflammation

Treating murine inflammatory diseases with an anti-erythrocyte antibody

Andrew R. Crow¹,²,³,*,
View ORCID ProfileRick Kapur¹,²,³,⁴,⁵,*,
Sandra Koernig⁶,
Ian K. Campbell⁶,
View ORCID ProfileChao-Ching Jen²,³,
View ORCID ProfilePatrick J. Mott²,³,
Danielle Marjoram²,³,
View ORCID ProfileRamsha Khan²,³,
Michael Kim²,³,
Jennifer Brasseit⁷,
View ORCID ProfileYoelys Cruz-Leal¹,²,³,
View ORCID ProfileAlaa Amash²,³,
Simrat Kahlon²,³,
View ORCID ProfileIssaka Yougbare¹,²,³,
View ORCID ProfileHeyu Ni¹,²,³,⁸,⁹,¹⁰,
Adrian W. Zuercher⁷,
View ORCID ProfileFabian Käsermann⁷,
John W. Semple¹,²,³,⁴,⁸,⁹,¹¹ and
View ORCID ProfileAlan H. Lazarus ¹,²,³,⁸,⁹,†

¹Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.
²Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
³Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.
⁴Department of Hematology and Transfusion Medicine, Lund University, Lund 221 84, Sweden.
⁵Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, Netherlands.
⁶CSL Limited, Bio21 Institute, University of Melbourne, Parkville, Victoria 3010, Australia.
⁷CSL Behring, Research, CSL Biologics Research Center, Bern, Switzerland.
⁸Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.
⁹Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
¹⁰Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
¹¹Department of Pharmacology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

↵†Corresponding author. Email: lazarusa{at}smh.ca

↵* These authors contributed equally to this work as co-first authors.

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Science Translational Medicine 21 Aug 2019:
Vol. 11, Issue 506, eaau8217
DOI: 10.1126/scitranslmed.aau8217

Andrew R. Crow

1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

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Rick Kapur

1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

4Department of Hematology and Transfusion Medicine, Lund University, Lund 221 84, Sweden.

5Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, Netherlands.

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Sandra Koernig

6CSL Limited, Bio21 Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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Ian K. Campbell

6CSL Limited, Bio21 Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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Chao-Ching Jen

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

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Patrick J. Mott

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

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Danielle Marjoram

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

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Ramsha Khan

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

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Michael Kim

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

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Jennifer Brasseit

7CSL Behring, Research, CSL Biologics Research Center, Bern, Switzerland.

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Yoelys Cruz-Leal

1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

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Alaa Amash

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

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Simrat Kahlon

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

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Issaka Yougbare

1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

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Heyu Ni

1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

8Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

9Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

10Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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Adrian W. Zuercher

7CSL Behring, Research, CSL Biologics Research Center, Bern, Switzerland.

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Fabian Käsermann

7CSL Behring, Research, CSL Biologics Research Center, Bern, Switzerland.

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John W. Semple

1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

4Department of Hematology and Transfusion Medicine, Lund University, Lund 221 84, Sweden.

8Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

9Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

11Department of Pharmacology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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Alan H. Lazarus

1Canadian Blood Services Centre for Innovation, Ottawa, Ontario K1G 4J5, Canada.

2Department of Laboratory Medicine and Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

3Toronto Platelet Immunobiology Group, Toronto, Ontario, M5B 1T8 Canada.

8Department of Medicine, St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada.

9Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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For correspondence: lazarusa@smh.ca

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