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Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

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Science Translational Medicine  14 Aug 2019:
Vol. 11, Issue 505, eaaw5680
DOI: 10.1126/scitranslmed.aaw5680

Article Information

vol. 11 no. 505

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 6, 2019
  • Accepted for publication July 1, 2019
  • .

Author Information

  1. E. Antonio Chiocca1,2,*,
  2. John S. Yu3,
  3. Rimas V. Lukas4,5,6,
  4. Isaac H. Solomon7,
  5. Keith L. Ligon7,
  6. Hiroshi Nakashima1,
  7. Daniel A. Triggs1,
  8. David A. Reardon2,
  9. Patrick Wen2,
  10. Brittany M. Stopa1,
  11. Ajay Naik1,
  12. Jeremy Rudnick3,
  13. Jethro L. Hu3,
  14. Priya Kumthekar4,5,
  15. Bakhtiar Yamini6,
  16. Jill Y. Buck8,
  17. Nathan Demars8,
  18. John A. Barrett8,
  19. Arnold B. Gelb8,
  20. John Zhou8,
  21. Francois Lebel8 and
  22. Laurence J. N. Cooper8,9
  1. 1Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  2. 2Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  3. 3Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  4. 4Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  5. 5Lou and Jean Malnati Brain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
  6. 6University of Chicago, Chicago, IL 60637, USA.
  7. 7Division of Neuropathology, Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  8. 8Ziopharm Oncology, Inc., One First Avenue, Parris Building 34, Navy Yard Plaza, Charlestown, Boston, MA 02129, USA.
  9. 9MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.
  1. *Corresponding author. Email: eachiocca{at}bwh.harvard.edu

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Article usage: August 2019 to November 2019

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Aug 201997542591888
Sep 2019700285173
Oct 2019801302162
Nov 20191634526