Research ArticleCancer

MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21

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Science Translational Medicine  14 Aug 2019:
Vol. 11, Issue 505, eaav7171
DOI: 10.1126/scitranslmed.aav7171

Article Information

vol. 11 no. 505

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 15, 2018
  • Resubmitted April 17, 2019
  • Accepted for publication July 12, 2019
  • .

Author Information

  1. Anna E. Vilgelm1,2,3,*,
  2. Nabil Saleh1,2,
  3. Rebecca Shattuck-Brandt1,2,
  4. Kelsie Riemenschneider4,
  5. Lauren Slesur2,
  6. Sheau-Chiann Chen5,
  7. C. Andrew Johnson1,2,
  8. Jinming Yang1,2,
  9. Ashlyn Blevins1,2,
  10. Chi Yan1,2,
  11. Douglas B. Johnson6,
  12. Rami N. Al-Rohil7,
  13. Ensar Halilovic8,
  14. Rondi M. Kauffmann9,
  15. Mark Kelley9,
  16. Gregory D. Ayers5 and
  17. Ann Richmond1,2
  1. 1Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USA.
  2. 2Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  3. 3Department of Pathology, Ohio State University, Columbus, OH 43210, USA.
  4. 4Department of Dermatology, University of Texas Southwestern, Medical Center, Dallas, TX 75390, USA.
  5. 5Division of Cancer Biostatistics, Department of Biostatistics, Vanderbilt University Center for Quantitative Sciences, Nashville, TN 37232, USA.
  6. 6Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  7. 7Department of Pathology, Duke University, Durham, NC 27708, USA.
  8. 8Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
  9. 9Division of Surgical Oncology, Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  1. *Corresponding author. Email: vilgelm.1{at}osu.edu

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Aug 201941611515579
Sep 2019342160117
Oct 2019227124112
Nov 20192387562
Dec 20197907442
Jan 20207516841
Feb 20207234634
Mar 20203654425
Apr 2020300

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