Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease

Jing Tian; Lan Guo; Shaomei Sui; Christopher Driskill; Aarron Phensy; Qi Wang; Esha Gauba; Jeffrey M. Zigman; Russell H. Swerdlow; Sven Kroener; Heng Du

doi:10.1126/scitranslmed.aav6278

Research ArticleAlzheimer’s Disease

Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease

Jing Tian¹,*,
Lan Guo¹,*,
Shaomei Sui ¹,²,
Christopher Driskill³,
Aarron Phensy³,
Qi Wang ¹,²,
Esha Gauba¹,
Jeffrey M. Zigman⁴,
Russell H. Swerdlow ⁵,
Sven Kroener³ and
Heng Du ¹,†

¹Department of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.
²Department of Neurology, Qianfoshan Hospital, Shandong First Medical University, Jinan, Shandong 250014, China.
³School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.
⁴Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
⁵Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA.

↵†Corresponding author. Email: heng.du{at}utdallas.edu

↵* These authors contributed equally to this work.

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Science Translational Medicine 14 Aug 2019:
Vol. 11, Issue 505, eaav6278
DOI: 10.1126/scitranslmed.aav6278

Jing Tian

Department of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.

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Lan Guo

Department of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.

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Shaomei Sui

Department of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.

Department of Neurology, Qianfoshan Hospital, Shandong First Medical University, Jinan, Shandong 250014, China.

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Christopher Driskill

School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.

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Aarron Phensy

School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.

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Qi Wang

Department of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.

Department of Neurology, Qianfoshan Hospital, Shandong First Medical University, Jinan, Shandong 250014, China.

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Esha Gauba

Department of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.

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Jeffrey M. Zigman

Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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Russell H. Swerdlow

Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA.

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Sven Kroener

School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.

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Heng Du

Department of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.

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For correspondence: heng.du@utdallas.edu

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Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease

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