Research ArticleAlzheimer’s Disease

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

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Science Translational Medicine  14 Aug 2019:
Vol. 11, Issue 505, eaau2291
DOI: 10.1126/scitranslmed.aau2291

Article Information

vol. 11 no. 505

PubMed: 
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History: 
  • Received for publication May 24, 2018
  • Accepted for publication April 5, 2019
  • .

Author Information

  1. Yuetiva Deming1,2,*,
  2. Fabia Filipello3,*,
  3. Francesca Cignarella3,*,
  4. Claudia Cantoni3,
  5. Simon Hsu1,
  6. Robert Mikesell3,
  7. Zeran Li1,
  8. Jorge L Del-Aguila1,
  9. Umber Dube1,
  10. Fabiana Geraldo Farias1,
  11. Joseph Bradley1,
  12. John Budde1,
  13. Laura Ibanez1,
  14. Maria Victoria Fernandez1,
  15. Kaj Blennow4,5,
  16. Henrik Zetterberg4,5,6,
  17. Amanda Heslegrave6,7,
  18. Per M Johansson8,
  19. Johan Svensson9,
  20. Bengt Nellgård10,
  21. Alberto Lleo11,12,
  22. Daniel Alcolea11,12,
  23. Jordi Clarimon11,12,
  24. Lorena Rami13,
  25. José Luis Molinuevo13,14,
  26. Marc Suárez-Calvet14,15,16,
  27. Estrella Morenas-Rodríguez15,17,
  28. Gernot Kleinberger15,17,18,
  29. Michael Ewers19,
  30. Oscar Harari1,20,21,
  31. Christian Haass16,17,22,
  32. Thomas J Brett20,23,
  33. Bruno A. Benitez1,20,21,,
  34. Celeste M. Karch1,20,21,,,
  35. Laura Piccio3,20,24,, and
  36. Carlos Cruchaga1,20,21,*,,
  1. 1Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  2. 2Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
  3. 3Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  4. 4Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
  5. 5Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.
  6. 6Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
  7. 7UK Dementia Research Institute at UCL, London, UK.
  8. 8Department of Clinical Sciences Helsingborg, Lund University, Lund, Sweden.
  9. 9Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden.
  10. 10Department of Anesthesiology, Sahlgrenska University Hospital, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden.
  11. 11Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  12. 12Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
  13. 13IDIBAPS, Alzheimer’s Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic, Barcelona, Spain.
  14. 14Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
  15. 15Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
  16. 16German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  17. 17Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  18. 18ISAR Bioscience GmbH, 2152 Planegg, Germany.
  19. 19Institute for Stroke and Dementia Research, University Hospital, LMU, Munich, Germany.
  20. 20Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.
  21. 21NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, MO 63110, USA.
  22. 22Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.
  23. 23Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  24. 24Brain and Mind Centre, University of Sydney, Sydney, NSW 2050, Australia.
  1. Corresponding author. Email: karchc{at}wustl.edu (C.M.K.); picciol{at}wustl.edu (L.P.); ccruchaga{at}wustl.edu (C. Cruchaga)
  • * These authors contributed equally to this work.

  • These authors contributed equally to this work.

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