Research ArticleCancer
Personalized circulating tumor DNA analysis to detect residual disease after neoadjuvant therapy in breast cancer
- Bradon R. McDonald1,
- Tania Contente-Cuomo1,
- Stephen-John Sammut2,
- Ahuva Odenheimer-Bergman1,
- Brenda Ernst3,
- Nieves Perdigones1,
- Suet-Feung Chin2,
- Maria Farooq1,
- Rosa Mejia4,
- Patricia A. Cronin3,
- Karen S. Anderson3,5,
- Heidi E. Kosiorek3,
- Donald W. Northfelt3,
- Ann E. McCullough3,
- Bhavika K. Patel3,
- Jeffrey N. Weitzel4,
- Thomas P. Slavin4,
- Carlos Caldas2,
- Barbara A. Pockaj3,* and
- Muhammed Murtaza1,3,*
- 1Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
- 2Department of Oncology and Cancer Research UK Cambridge Institute and Cancer Centre, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK.
- 3Mayo Clinic, Scottsdale, AZ 85259, USA.
- 4City of Hope, Duarte, CA 91010, USA.
- 5Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA.
- ↵*Corresponding author. Email: mmurtaza{at}tgen.org (M.M.); pockaj.barbara{at}mayo.edu (B.A.P.)
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Science Translational Medicine 07 Aug 2019:
Vol. 11, Issue 504, eaax7392
DOI: 10.1126/scitranslmed.aax7392
Vol. 11, Issue 504, eaax7392
DOI: 10.1126/scitranslmed.aax7392
Bradon R. McDonald
Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Tania Contente-Cuomo
Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Stephen-John Sammut
Department of Oncology and Cancer Research UK Cambridge Institute and Cancer Centre, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK.
Ahuva Odenheimer-Bergman
Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Brenda Ernst
Mayo Clinic, Scottsdale, AZ 85259, USA.
Nieves Perdigones
Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Suet-Feung Chin
Department of Oncology and Cancer Research UK Cambridge Institute and Cancer Centre, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK.
Maria Farooq
Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Rosa Mejia
City of Hope, Duarte, CA 91010, USA.
Patricia A. Cronin
Mayo Clinic, Scottsdale, AZ 85259, USA.
Karen S. Anderson
Mayo Clinic, Scottsdale, AZ 85259, USA.Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA.
Heidi E. Kosiorek
Mayo Clinic, Scottsdale, AZ 85259, USA.
Donald W. Northfelt
Mayo Clinic, Scottsdale, AZ 85259, USA.
Ann E. McCullough
Mayo Clinic, Scottsdale, AZ 85259, USA.
Bhavika K. Patel
Mayo Clinic, Scottsdale, AZ 85259, USA.
Jeffrey N. Weitzel
City of Hope, Duarte, CA 91010, USA.
Thomas P. Slavin
City of Hope, Duarte, CA 91010, USA.
Carlos Caldas
Department of Oncology and Cancer Research UK Cambridge Institute and Cancer Centre, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, UK.
Barbara A. Pockaj
Mayo Clinic, Scottsdale, AZ 85259, USA.
Muhammed Murtaza
Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.Mayo Clinic, Scottsdale, AZ 85259, USA.
