Research ArticleHIV
Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model
- Kim Anthony-Gonda1,*,
- Ariola Bardhi2,*,
- Alex Ray2,
- Nina Flerin2,
- Mengyan Li2,
- Weizao Chen3,
- Christina Ochsenbauer4,
- John C. Kappes4,5,
- Winfried Krueger1,
- Andrew Worden1,
- Dina Schneider1,
- Zhongyu Zhu1,
- Rimas Orentas1,†,
- Dimiter S. Dimitrov6,‡,
- Harris Goldstein2,‡ and
- Boro Dropulić1,‡
- 1Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
- 2Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 3Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
- 4Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- 5Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, AL 35294, USA.
- 6Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
- ↵‡Corresponding author. Email: boro.dropulic{at}lentigen.com (B.D.); harris.goldstein{at}einstein.yu.edu (H.G.); dsd116{at}pitt.edu (D.S.D.)
↵* These authors contributed equally to this work.
↵† Present address: Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, Seattle, WA 98101, USA.
See allHide authors and affiliations
Science Translational Medicine 07 Aug 2019:
Vol. 11, Issue 504, eaav5685
DOI: 10.1126/scitranslmed.aav5685
