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Research ArticleHIV
Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model
- View ORCID ProfileKim Anthony-Gonda1,*,
- View ORCID ProfileAriola Bardhi2,*,
- View ORCID ProfileAlex Ray2,
- View ORCID ProfileNina Flerin2,
- View ORCID ProfileMengyan Li2,
- Weizao Chen3,
- View ORCID ProfileChristina Ochsenbauer4,
- View ORCID ProfileJohn C. Kappes4,5,
- View ORCID ProfileWinfried Krueger1,
- View ORCID ProfileAndrew Worden1,
- Dina Schneider1,
- Zhongyu Zhu1,
- View ORCID ProfileRimas Orentas1,†,
- View ORCID ProfileDimiter S. Dimitrov6,‡,
- View ORCID ProfileHarris Goldstein2,‡ and
- View ORCID ProfileBoro Dropulić1,‡
- 1Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
- 2Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 3Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
- 4Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- 5Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, AL 35294, USA.
- 6Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
- ↵‡Corresponding author. Email: boro.dropulic{at}lentigen.com (B.D.); harris.goldstein{at}einstein.yu.edu (H.G.); dsd116{at}pitt.edu (D.S.D.)
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Science Translational Medicine 07 Aug 2019:
Vol. 11, Issue 504, eaav5685
DOI: 10.1126/scitranslmed.aav5685
Vol. 11, Issue 504, eaav5685
DOI: 10.1126/scitranslmed.aav5685
Kim Anthony-Gonda
1Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
Ariola Bardhi
2Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Alex Ray
2Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Nina Flerin
2Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Mengyan Li
2Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Weizao Chen
3Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Christina Ochsenbauer
4Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
John C. Kappes
4Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
5Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, AL 35294, USA.
Winfried Krueger
1Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
Andrew Worden
1Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
Dina Schneider
1Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
Zhongyu Zhu
1Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
Rimas Orentas
1Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
Dimiter S. Dimitrov
6Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Harris Goldstein
2Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Boro Dropulić
1Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
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