Research ArticleHIV

Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model

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Science Translational Medicine  07 Aug 2019:
Vol. 11, Issue 504, eaav5685
DOI: 10.1126/scitranslmed.aav5685

Article Information

vol. 11 no. 504

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History: 
  • Received for publication September 28, 2018
  • Resubmitted February 20, 2019
  • Accepted for publication July 3, 2019
  • .

Author Information

  1. Kim Anthony-Gonda1,*,
  2. Ariola Bardhi2,*,
  3. Alex Ray2,
  4. Nina Flerin2,
  5. Mengyan Li2,
  6. Weizao Chen3,
  7. Christina Ochsenbauer4,
  8. John C. Kappes4,5,
  9. Winfried Krueger1,
  10. Andrew Worden1,
  11. Dina Schneider1,
  12. Zhongyu Zhu1,
  13. Rimas Orentas1,,
  14. Dimiter S. Dimitrov6,,
  15. Harris Goldstein2, and
  16. Boro Dropulić1,
  1. 1Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
  2. 2Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  3. 3Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
  4. 4Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  5. 5Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, AL 35294, USA.
  6. 6Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  1. Corresponding author. Email: boro.dropulic{at}lentigen.com (B.D.); harris.goldstein{at}einstein.yu.edu (H.G.); dsd116{at}pitt.edu (D.S.D.)
  • * These authors contributed equally to this work.

  • Present address: Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, Seattle, WA 98101, USA.

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Aug 2019937524331091
Sep 2019720244187
Oct 2019831258191
Nov 2019592132119
Dec 20194485550