Research ArticleCystic Fibrosis

Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies

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Science Translational Medicine  07 Aug 2019:
Vol. 11, Issue 504, eaav3505
DOI: 10.1126/scitranslmed.aav3505

Mucociliary microscopy

Epithelial ion transport is dysfunctional in individuals with cystic fibrosis (CF), a disease caused by mutations in the CF transmembrane conductance regulator that results in increased mucus accumulation, infection, and loss of lung function. Leung et al. developed an intranasal optical imaging probe with subcellular resolution that detected alterations in airway mucociliary transport in individuals with CF. Along with increased reflectivity in mucus and thicker mucus layers, the authors found areas of the epithelium lacking cilia, thinning of the periciliary liquid layer, and delayed mucociliary transport rate. Results suggest that intranasal micro-optical coherence tomography could help monitor disease status in individuals with respiratory conditions.

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