Research ArticleGlioblastoma

Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells

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Science Translational Medicine  07 Aug 2019:
Vol. 11, Issue 504, eaau4972
DOI: 10.1126/scitranslmed.aau4972

Article Information

vol. 11 no. 504

Print ISSN: 
Online ISSN: 
  • Received for publication June 16, 2018
  • Resubmitted March 6, 2019
  • Accepted for publication June 24, 2019
  • .

Author Information

  1. Xiuxing Wang1,*,
  2. Kailin Yang2,3,*,
  3. Qiulian Wu1,
  4. Leo J. Y. Kim1,4,
  5. Andrew R. Morton5,
  6. Ryan C. Gimple1,4,
  7. Briana C. Prager1,3,4,
  8. Yu Shi6,
  9. Wenchao Zhou7,
  10. Shruti Bhargava1,
  11. Zhe Zhu1,
  12. Li Jiang1,
  13. Weiwei Tao7,
  14. Zhixin Qiu1,
  15. Linjie Zhao1,
  16. Guoxing Zhang1,
  17. Xiqing Li1,
  18. Sameer Agnihotri8,
  19. Paul S. Mischel9,
  20. Stephen C. Mack10,
  21. Shideng Bao7 and
  22. Jeremy N. Rich1,
  1. 1Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
  2. 2Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH 44195, USA.
  3. 3Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA.
  4. 4Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
  5. 5Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
  6. 6Institute of Pathology and Southwest Cancer Center, Southwest Hospital, The Third Military Medical University, and The Key Laboratory of Tumor Immunopathology, The Ministry of Education of China, Chongqing 400038, China.
  7. 7Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA.
  8. 8Department of Neurological Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
  9. 9Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.
  10. 10Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
  1. Corresponding author. Email: drjeremyrich{at}
  • * These authors contributed equally to this work.


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Article usage: August 2019 to January 2020

Aug 201951211588746
Sep 2019566163145
Oct 2019351137123
Nov 20192579376
Dec 20198348474
Jan 20203563832

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