07 August 2019
Vol 11, Issue 504

About The Cover

Cover image expansion

ONLINE COVER Manipulating Metabolic Machinery. Mutation-specific drugs have shown some efficacy in reducing glioblastoma tumor growth; however, treatments do not eradicate glioblastoma stem cells (GSCs), a subpopulation of multipotent tumor cells responsible for drug resistance and tumor recurrence. This image summarizes in vivo data from Wang and colleagues, who tested a variety of treatments in mouse models of glioblastoma. After discovering that pyrimidine biosynthesis is increased in GSCs and contributes to GSC maintenance, Wang et al. combined mutation-specific therapies (left and right) with pyrimidine biosynthesis inhibition (middle). Combination therapy increased tumor cell death and improved survival in mice compared to either treatment alone. [CREDIT: LAN-TAO GOU]