Research ArticleDrug Delivery

Snake fang–inspired stamping patch for transdermal delivery of liquid formulations

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Science Translational Medicine  31 Jul 2019:
Vol. 11, Issue 503, eaaw3329
DOI: 10.1126/scitranslmed.aaw3329

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Bioinspired drug delivery

Topical formulations, transdermal patches, and microneedles can be used for drug delivery, avoiding the pain associated with hypodermic needle injections. Bae et al. developed flexible patches using microneedles to rapidly deliver liquid formulations through the skin. Inspired by rear-fanged snakes, the authors fabricated microneedles with open grooves that transdermally delivered dye-labeled proteinaceous solutions, liquid anesthetic, and a vaccine to guinea pigs and mice. Mice showed similar protection against influenza when immunized by microneedle patch or intramuscular injection. This flexible patch platform offers a versatile method of liquid drug delivery.

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