Research ArticleAutoimmunity

Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain

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Science Translational Medicine  24 Jul 2019:
Vol. 11, Issue 502, eaaw1736
DOI: 10.1126/scitranslmed.aaw1736

Article Information

vol. 11 no. 502

PubMed: 
Print ISSN: 
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History: 
  • Received for publication November 25, 2018
  • Resubmitted February 24, 2019
  • Accepted for publication July 3, 2019
  • .

Author Information

  1. James R. Burke1,*,
  2. Lihong Cheng1,
  3. Kathleen M. Gillooly1,
  4. Joann Strnad1,
  5. Adriana Zupa-Fernandez1,
  6. Ian M. Catlett2,
  7. Yifan Zhang1,
  8. Elizabeth M. Heimrich1,
  9. Kim W. McIntyre1,
  10. Mark D. Cunningham3,
  11. Julie A. Carman3,
  12. Xiadi Zhou1,
  13. Dana Banas3,
  14. Charu Chaudhry4,
  15. Sha Li4,
  16. Celia D’Arienzo5,
  17. Anjaneya Chimalakonda5,
  18. XiaoXia Yang1,
  19. Jenny H. Xie1,
  20. Jian Pang1,
  21. Qihong Zhao1,
  22. Shawn M. Rose2,
  23. Jinwen Huang1,
  24. Ryan M. Moslin6,
  25. Stephen T. Wrobleski6,
  26. David S. Weinstein6 and
  27. Luisa M. Salter-Cid1
  1. 1Immunosciences Discovery Biology, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  2. 2Innovative Medicines Development, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  3. 3Translational Medicine, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  4. 4Leads Discovery and Optimization, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  5. 5Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  6. 6Immunosciences Discovery Chemistry, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543, USA.
  1. *Corresponding author. Email: james.burke{at}bms.com

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Article usage: July 2019 to November 2019

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Jul 201926145691121
Aug 2019423535371
Sep 2019650206153
Oct 201929614096
Nov 20191544937