Research ArticleBONE HEALING

Multifunctional scaffolds for facile implantation, spontaneous fixation, and accelerated long bone regeneration in rodents

See allHide authors and affiliations

Science Translational Medicine  24 Jul 2019:
Vol. 11, Issue 502, eaau7411
DOI: 10.1126/scitranslmed.aau7411

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Mending with memory

Grafts or osteoconductive scaffolds need to fill large defect volumes to heal critical-size bone defects, but manufacturing and implanting materials to fit snugly within defects can be challenging. Zhang et al. designed compressible macroporous synthetic scaffolds that swelled to their original shape when hydrated (shape-memory). Cylindrical scaffolds implanted into femoral defects in rats delivered a low dose of bone morphogenetic protein while degrading over time to enhance bone formation. Results demonstrate how osteoconductive scaffolds can be engineered to stabilize graft fixation with facile surgical handing, warranting testing in larger animal models.

View Full Text