Research ArticleBioengineering

Fluid assessment in dialysis patients by point-of-care magnetic relaxometry

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Science Translational Medicine  24 Jul 2019:
Vol. 11, Issue 502, eaau1749
DOI: 10.1126/scitranslmed.aau1749

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Detecting fluid imbalance

The kidneys play an important role in maintaining fluid balance within the body. Patients with end-stage renal disease often experience swelling in the lower limbs due to excess extracellular fluid, and fluid status must be closely monitored during hemodialysis. Colucci and colleagues devised a portable nuclear magnetic resonance (NMR) sensor to assess tissue fluid status. Changes in extracellular fluid space in leg muscles of patients undergoing dialysis detected by the NMR sensor were similar to NMR relaxometry measured by magnetic resonance imaging. Results suggest that the nonimaging NMR sensors can provide objective, rapid bedside evaluation of fluid status in patients.

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