Research ArticleGUT MICROBIOTA
The gut microbiota influences skeletal muscle mass and function in mice
- View ORCID ProfileShawon Lahiri1,2,*,†,
- View ORCID ProfileHyejin Kim3,
- View ORCID ProfileIsabel Garcia-Perez4,
- View ORCID ProfileMusarrat Maisha Reza1,5,
- View ORCID ProfileKatherine A. Martin3,
- View ORCID ProfileParag Kundu3,6,
- View ORCID ProfileLaura M. Cox7,
- View ORCID ProfileJoel Selkrig3,‡,
- View ORCID ProfileJoram M. Posma4,
- View ORCID ProfileHongbo Zhang8,§,
- View ORCID ProfileParasuraman Padmanabhan3,
- View ORCID ProfileCatherine Moret2,
- View ORCID ProfileBalázs Gulyás9,10,
- Martin J. Blaser11,12,
- View ORCID ProfileJohan Auwerx8,
- View ORCID ProfileElaine Holmes4,
- Jeremy Nicholson13,
- Walter Wahli2,3,14 and
- View ORCID ProfileSven Pettersson1,3,6,†
- 1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
- 2Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
- 3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
- 4Division of Computational and Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW72AZ, UK.
- 5School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
- 6Singapore Center for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore.
- 7Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 8Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
- 9Department of Neuroscience and Mental Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
- 10Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
- 11Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.
- 12Medical Service, VA New York Harbor Healthcare System, New York, NY 10010, USA.
- 13Australian National Phenome Center, Murdoch University, WA 6150, Australia.
- 14INRA ToxAlim Integrative Toxicology and Metabolism UMR1331, Chemin de Tournefeuille, Toulouse Cedex, France.
- ↵†Corresponding author. Email: sven.pettersson{at}ki.se (S.P.); shawonlahiri{at}gmail.com (S.L.)
↵* Present address: Swedish Research Council, Stockholm, Sweden.
↵‡ Present address: European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
↵§ Present address: Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Department of Histology and Embryology of Zhongshan School of Medicine, Sun-Yat Sen University, Guangzhou, China.
See allHide authors and affiliations
Science Translational Medicine 24 Jul 2019:
Vol. 11, Issue 502, eaan5662
DOI: 10.1126/scitranslmed.aan5662
Vol. 11, Issue 502, eaan5662
DOI: 10.1126/scitranslmed.aan5662
Shawon Lahiri
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
2Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Hyejin Kim
3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Isabel Garcia-Perez
4Division of Computational and Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW72AZ, UK.
Musarrat Maisha Reza
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
5School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Katherine A. Martin
3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Parag Kundu
3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
6Singapore Center for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore.
Laura M. Cox
7Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Joel Selkrig
3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Joram M. Posma
4Division of Computational and Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW72AZ, UK.
Hongbo Zhang
8Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Parasuraman Padmanabhan
3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Catherine Moret
2Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Balázs Gulyás
9Department of Neuroscience and Mental Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
10Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Martin J. Blaser
11Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.
12Medical Service, VA New York Harbor Healthcare System, New York, NY 10010, USA.
Johan Auwerx
8Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Elaine Holmes
4Division of Computational and Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW72AZ, UK.
Jeremy Nicholson
13Australian National Phenome Center, Murdoch University, WA 6150, Australia.
Walter Wahli
2Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
14INRA ToxAlim Integrative Toxicology and Metabolism UMR1331, Chemin de Tournefeuille, Toulouse Cedex, France.
Sven Pettersson
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
6Singapore Center for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore.
