The gut microbiota influences skeletal muscle mass and function in mice

Shawon Lahiri; Hyejin Kim; Isabel Garcia-Perez; Musarrat Maisha Reza; Katherine A. Martin; Parag Kundu; Laura M. Cox; Joel Selkrig; Joram M. Posma; Hongbo Zhang; Parasuraman Padmanabhan; Catherine Moret; Balázs Gulyás; Martin J. Blaser; Johan Auwerx; Elaine Holmes; Jeremy Nicholson; Walter Wahli; Sven Pettersson

doi:10.1126/scitranslmed.aan5662

Research ArticleGUT MICROBIOTA

The gut microbiota influences skeletal muscle mass and function in mice

View ORCID ProfileShawon Lahiri ¹,²,*,†,
View ORCID ProfileHyejin Kim³,
View ORCID ProfileIsabel Garcia-Perez ⁴,
View ORCID ProfileMusarrat Maisha Reza¹,⁵,
View ORCID ProfileKatherine A. Martin³,
View ORCID ProfileParag Kundu³,⁶,
View ORCID ProfileLaura M. Cox⁷,
View ORCID ProfileJoel Selkrig³,‡,
View ORCID ProfileJoram M. Posma ⁴,
View ORCID ProfileHongbo Zhang⁸,§,
View ORCID ProfileParasuraman Padmanabhan³,
View ORCID ProfileCatherine Moret²,
View ORCID ProfileBalázs Gulyás⁹,¹⁰,
Martin J. Blaser¹¹,¹²,
View ORCID ProfileJohan Auwerx⁸,
View ORCID ProfileElaine Holmes⁴,
Jeremy Nicholson¹³,
Walter Wahli²,³,¹⁴ and
View ORCID ProfileSven Pettersson¹,³,⁶,†

¹Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
²Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
³Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
⁴Division of Computational and Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW72AZ, UK.
⁵School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
⁶Singapore Center for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore.
⁷Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
⁸Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁹Department of Neuroscience and Mental Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
¹⁰Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
¹¹Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.
¹²Medical Service, VA New York Harbor Healthcare System, New York, NY 10010, USA.
¹³Australian National Phenome Center, Murdoch University, WA 6150, Australia.
¹⁴INRA ToxAlim Integrative Toxicology and Metabolism UMR1331, Chemin de Tournefeuille, Toulouse Cedex, France.

↵†Corresponding author. Email: sven.pettersson{at}ki.se (S.P.); shawonlahiri{at}gmail.com (S.L.)

↵* Present address: Swedish Research Council, Stockholm, Sweden.
↵‡ Present address: European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
↵§ Present address: Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Department of Histology and Embryology of Zhongshan School of Medicine, Sun-Yat Sen University, Guangzhou, China.

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Science Translational Medicine 24 Jul 2019:
Vol. 11, Issue 502, eaan5662
DOI: 10.1126/scitranslmed.aan5662

Shawon Lahiri

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

2Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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For correspondence: sven.pettersson@ki.se shawonlahiri@gmail.com

Hyejin Kim

3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

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Isabel Garcia-Perez

4Division of Computational and Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW72AZ, UK.

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ORCID record for Isabel Garcia-Perez

Musarrat Maisha Reza

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

5School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

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Katherine A. Martin

3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

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Parag Kundu

3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

6Singapore Center for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore.

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Laura M. Cox

7Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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Joel Selkrig

3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

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Joram M. Posma

4Division of Computational and Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW72AZ, UK.

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Hongbo Zhang

8Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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Parasuraman Padmanabhan

3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

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Catherine Moret

2Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

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Balázs Gulyás

9Department of Neuroscience and Mental Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

10Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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Martin J. Blaser

11Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.

12Medical Service, VA New York Harbor Healthcare System, New York, NY 10010, USA.

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Johan Auwerx

8Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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Elaine Holmes

4Division of Computational and Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW72AZ, UK.

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Jeremy Nicholson

13Australian National Phenome Center, Murdoch University, WA 6150, Australia.

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Walter Wahli

2Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

14INRA ToxAlim Integrative Toxicology and Metabolism UMR1331, Chemin de Tournefeuille, Toulouse Cedex, France.

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Sven Pettersson

1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

6Singapore Center for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore.

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For correspondence: sven.pettersson@ki.se shawonlahiri@gmail.com

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Of microbial metabolites and muscle

Skeletal muscle is important not only for locomotion but also for regulating metabolic function. Lahiri et al. studied the interactions between the gut microbiota and skeletal muscle in mice. They identified genes and signaling pathways involved in the regulation of skeletal muscle mass and function that responded to cues from the gut microbiota. Additional biochemical and functional analysis also revealed the influence of the gut microbiota on the function of neuromuscular junctions. These findings open the door to a better understanding of the role of the gut microbiota in the mechanisms underlying loss of muscle mass.

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The gut microbiota influences skeletal muscle mass and function in mice

Of microbial metabolites and muscle

Science Translational Medicine

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