Research ArticleGUT MICROBIOTA

The gut microbiota influences skeletal muscle mass and function in mice

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Science Translational Medicine  24 Jul 2019:
Vol. 11, Issue 502, eaan5662
DOI: 10.1126/scitranslmed.aan5662

Of microbial metabolites and muscle

Skeletal muscle is important not only for locomotion but also for regulating metabolic function. Lahiri et al. studied the interactions between the gut microbiota and skeletal muscle in mice. They identified genes and signaling pathways involved in the regulation of skeletal muscle mass and function that responded to cues from the gut microbiota. Additional biochemical and functional analysis also revealed the influence of the gut microbiota on the function of neuromuscular junctions. These findings open the door to a better understanding of the role of the gut microbiota in the mechanisms underlying loss of muscle mass.

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