Contents
24 July 2019
Vol 11, Issue 502
Vol 11, Issue 502
Review
- The 1918 influenza pandemic: 100 years of questions answered and unanswered
This Review summarizes key findings about the “Spanish” influenza pandemic and addresses implications for current pandemic response and control, including vaccination optimization.
Research Articles
- Fluid assessment in dialysis patients by point-of-care magnetic relaxometry
Portable nuclear magnetic resonance (NMR) sensors enable quantitative diagnostic measurements of fluid status in patients with end-stage renal disease.
- Multifunctional scaffolds for facile implantation, spontaneous fixation, and accelerated long bone regeneration in rodents
Self-stiffening, macroporous, shape-memory scaffolds delivering a low dose of osteogenic factors accelerate segmental long bone regeneration in rats.
- AAV-delivered eCD4-Ig protects rhesus macaques from high-dose SIVmac239 challenges
AAV-expressed eCD4-Ig protects rhesus macaques from SIVmac239.
- Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain
An allosteric TYK2 inhibitor ameliorates disease in murine autoimmune models and blocks type I interferon responses in humans.
- The gut microbiota influences skeletal muscle mass and function in mice
Transplanting the gut microbiota of pathogen-free mice into germ-free mice improves skeletal muscle mass and strength.
Editors' Choice
- More blurred lines with innate lymphoid cells
Group 2 innate lymphoid cells might form a pool of innate cells with capabilities beyond fighting parasites and mediating allergic diseases.
- How to save a life
A zebrafish model was used to identify successful therapy for a child with lymphatic anomaly.
- Bedazzled biomaterials: Crystallized drugs prevent implant fibrosis
Crystallized anti-inflammatory drug formulations incorporated into biomaterial devices reduce fibrotic response when implanted in animal models.
About The Cover
ONLINE COVER Small Sensor, Meaningful Measurements. Fluid volume is carefully monitored in patients with heart and renal disease, typically by tracking changes in body weight, by palpation during physical clinical exams, and by magnetic resonance imaging (left). Colucci et al. developed a portable nuclear magnetic resonance (NMR) sensor (right) to expand access to quantitative assessment of fluid status. When placed adjacent to the lower leg, the NMR sensor detected changes in extracellular fluid in individuals with end-stage renal disease undergoing hemodialysis. This small, nonimaging NMR sensor could provide rapid, bedside evaluation of fluid status to manage fluid overload. [CREDIT: ALEXLMX/ISTOCKPHOTO, COLUCCI ET AL./SCIENCE TRANSLATIONAL MEDICINE]
