24 July 2019
Vol 11, Issue 502

About The Cover

Cover image expansion

ONLINE COVER Small Sensor, Meaningful Measurements. Fluid volume is carefully monitored in patients with heart and renal disease, typically by tracking changes in body weight, by palpation during physical clinical exams, and by magnetic resonance imaging (left). Colucci et al. developed a portable nuclear magnetic resonance (NMR) sensor (right) to expand access to quantitative assessment of fluid status. When placed adjacent to the lower leg, the NMR sensor detected changes in extracellular fluid in individuals with end-stage renal disease undergoing hemodialysis. This small, nonimaging NMR sensor could provide rapid, bedside evaluation of fluid status to manage fluid overload. [CREDIT: ALEXLMX/ISTOCKPHOTO, COLUCCI ET AL./SCIENCE TRANSLATIONAL MEDICINE]