Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

Emily E. Marshall; Daniel Malouli; Scott G. Hansen; Roxanne M. Gilbride; Colette M. Hughes; Abigail B. Ventura; Emily Ainslie; Andrea N. Selseth; Julia C. Ford; David Burke; Craig N. Kreklywich; Jennie Womack; Alfred W. Legasse; Michael K. Axthelm; Christoph Kahl; Daniel Streblow; Paul T. Edlefsen; Louis J. Picker; Klaus Früh

doi:10.1126/scitranslmed.aaw2603

Research ArticleVaccines

Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

Emily E. Marshall¹,*,†,
Daniel Malouli¹,*,
Scott G. Hansen¹,*,
Roxanne M. Gilbride¹,
Colette M. Hughes¹,
Abigail B. Ventura¹,
Emily Ainslie¹,
Andrea N. Selseth¹,
Julia C. Ford¹,
David Burke¹,
Craig N. Kreklywich¹,
Jennie Womack¹,
Alfred W. Legasse¹,
Michael K. Axthelm ¹,
Christoph Kahl¹,‡,
Daniel Streblow¹,
Paul T. Edlefsen²,
Louis J. Picker ¹,§ and
Klaus Früh ¹,§

¹Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
²Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

↵§Corresponding author. Email: pickerl{at}ohsu.edu (L.J.P.); fruehk{at}ohsu.edu (K.F.)

↵* These authors contributed equally to this work.
↵† Present address: Vir Biotechnology, 4640 SW Macadam Avenue, Portland, OR 97239, USA.
↵‡ Present address: Atara Biotherapeutics, 611 Gateway Boulevard Suite 900, South San Francisco, CA 94080, USA.

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Science Translational Medicine 17 Jul 2019:
Vol. 11, Issue 501, eaaw2603
DOI: 10.1126/scitranslmed.aaw2603

Emily E. Marshall

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Daniel Malouli

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Scott G. Hansen

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Roxanne M. Gilbride

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Colette M. Hughes

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Abigail B. Ventura

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Emily Ainslie

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Andrea N. Selseth

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Julia C. Ford

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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David Burke

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Craig N. Kreklywich

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Jennie Womack

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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ORCID record for Jennie Womack

Alfred W. Legasse

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Michael K. Axthelm

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Christoph Kahl

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Daniel Streblow

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Paul T. Edlefsen

Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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Louis J. Picker

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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For correspondence: pickerl@ohsu.edu fruehk@ohsu.edu

Klaus Früh

Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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ORCID record for Klaus Früh
For correspondence: pickerl@ohsu.edu fruehk@ohsu.edu

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