Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

Emily E. Marshall; Daniel Malouli; Scott G. Hansen; Roxanne M. Gilbride; Colette M. Hughes; Abigail B. Ventura; Emily Ainslie; Andrea N. Selseth; Julia C. Ford; David Burke; Craig N. Kreklywich; Jennie Womack; Alfred W. Legasse; Michael K. Axthelm; Christoph Kahl; Daniel Streblow; Paul T. Edlefsen; Louis J. Picker; Klaus Früh

doi:10.1126/scitranslmed.aaw2603

Research ArticleVaccines

Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

View ORCID ProfileEmily E. Marshall¹,*,†,
View ORCID ProfileDaniel Malouli¹,*,
View ORCID ProfileScott G. Hansen¹,*,
Roxanne M. Gilbride¹,
Colette M. Hughes¹,
Abigail B. Ventura¹,
View ORCID ProfileEmily Ainslie¹,
Andrea N. Selseth¹,
View ORCID ProfileJulia C. Ford¹,
David Burke¹,
Craig N. Kreklywich¹,
View ORCID ProfileJennie Womack¹,
View ORCID ProfileAlfred W. Legasse¹,
View ORCID ProfileMichael K. Axthelm ¹,
View ORCID ProfileChristoph Kahl¹,‡,
Daniel Streblow¹,
View ORCID ProfilePaul T. Edlefsen²,
View ORCID ProfileLouis J. Picker ¹,§ and
View ORCID ProfileKlaus Früh ¹,§

¹Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
²Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

↵§Corresponding author. Email: pickerl{at}ohsu.edu (L.J.P.); fruehk{at}ohsu.edu (K.F.)

↵* These authors contributed equally to this work.
↵† Present address: Vir Biotechnology, 4640 SW Macadam Avenue, Portland, OR 97239, USA.
↵‡ Present address: Atara Biotherapeutics, 611 Gateway Boulevard Suite 900, South San Francisco, CA 94080, USA.

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Science Translational Medicine 17 Jul 2019:
Vol. 11, Issue 501, eaaw2603
DOI: 10.1126/scitranslmed.aaw2603

Emily E. Marshall

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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ORCID record for Emily E. Marshall

Daniel Malouli

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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ORCID record for Daniel Malouli

Scott G. Hansen

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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ORCID record for Scott G. Hansen

Roxanne M. Gilbride

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Colette M. Hughes

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Abigail B. Ventura

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Emily Ainslie

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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ORCID record for Emily Ainslie

Andrea N. Selseth

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Julia C. Ford

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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ORCID record for Julia C. Ford

David Burke

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Craig N. Kreklywich

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Jennie Womack

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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ORCID record for Jennie Womack

Alfred W. Legasse

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Michael K. Axthelm

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Christoph Kahl

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Daniel Streblow

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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Paul T. Edlefsen

2Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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Louis J. Picker

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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For correspondence: pickerl@ohsu.edu fruehk@ohsu.edu

Klaus Früh

1Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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ORCID record for Klaus Früh
For correspondence: pickerl@ohsu.edu fruehk@ohsu.edu

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