Research ArticleCancer

A multimodality test to guide the management of patients with a pancreatic cyst

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Science Translational Medicine  17 Jul 2019:
Vol. 11, Issue 501, eaav4772
DOI: 10.1126/scitranslmed.aav4772

Article Information

vol. 11 no. 501

PubMed: 
Print ISSN: 
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History: 
  • Received for publication September 21, 2018
  • Resubmitted January 7, 2019
  • Accepted for publication June 24, 2019
  • .

Author Information

  1. Simeon Springer1,2,*,
  2. David L. Masica2,3,4,*,
  3. Marco Dal Molin2,5,*,
  4. Christopher Douville1,2,3,4,
  5. Christopher J. Thoburn1,2,
  6. Bahman Afsari2,6,
  7. Lu Li1,2,
  8. Joshua D. Cohen1,2,3,
  9. Elizabeth Thompson2,5,
  10. Peter J. Allen7,
  11. David S. Klimstra8,
  12. Mark A. Schattner9,
  13. C. Max Schmidt10,
  14. Michele Yip-Schneider10,
  15. Rachel E. Simpson10,
  16. Carlos Fernandez-Del Castillo11,
  17. Mari Mino-Kenudson12,
  18. William Brugge13,
  19. Randall E. Brand14,
  20. Aatur D. Singhi15,
  21. Aldo Scarpa16,17,
  22. Rita Lawlor16,17,
  23. Roberto Salvia18,
  24. Giuseppe Zamboni19,
  25. Seung-Mo Hong20,
  26. Dae Wook Hwang21,
  27. Jin-Young Jang22,
  28. Wooil Kwon22,
  29. Niall Swan23,
  30. Justin Geoghegan24,
  31. Massimo Falconi25,
  32. Stefano Crippa25,
  33. Claudio Doglioni26,
  34. Jorge Paulino27,
  35. Richard D. Schulick28,
  36. Barish H. Edil28,
  37. Walter Park29,
  38. Shinichi Yachida30,
  39. Susumu Hijioka31,
  40. Jeanin van Hooft32,
  41. Jin He33,
  42. Matthew J. Weiss33,
  43. Richard Burkhart33,
  44. Martin Makary33,
  45. Marcia I. Canto34,
  46. Michael G. Goggins2,5,6,34,
  47. Janine Ptak1,2,
  48. Lisa Dobbyn1,2,
  49. Joy Schaefer1,2,
  50. Natalie Sillman1,2,
  51. Maria Popoli1,2,
  52. Alison P. Klein1,2,6,
  53. Cristian Tomasetti2,35,,
  54. Rachel Karchin2,3,4,6,,
  55. Nickolas Papadopoulos1,2,
  56. Kenneth W. Kinzler1,2,
  57. Bert Vogelstein1,2,,
  58. Christopher L. Wolfgang2,6,33,,
  59. Ralph H. Hruban1,2,5,6, and
  60. Anne Marie Lennon1,2,6,33,34,36,
  1. 1Ludwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.
  2. 2Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21287, USA.
  3. 3Department of Biomedical Engineering, Johns Hopkins Medical Institutions, Johns Hopkins University, Baltimore, MD 21287, USA.
  4. 4Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
  5. 5Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA.
  6. 6Department of Oncology, Johns Hopkins University, Baltimore, MD 21287, USA.
  7. 7Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  8. 8Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  9. 9Department of Gastroenterology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  10. 10Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  11. 11Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
  12. 12Department of Histopathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  13. 13Department of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  14. 14Department of Medicine, University of Pittsburgh, Pittsburgh PA 15213, USA.
  15. 15Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  16. 16ARC-Net Research Centre, University and Hospital Trust of Verona, Verona 37134, Italy.
  17. 17Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona 37134, Italy.
  18. 18General and Pancreatic Surgery, Pancreas Institute, University and Hospital Trust of Verona, Verona 37134, Italy.
  19. 19Department of Pathology, Ospedale Sacro Cuore-Don Calabria, Negrar 37024, Italy,
  20. 20Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
  21. 21Hepatobiliary and Pancreas Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
  22. 22Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.
  23. 23Department of Histopathology, St. Vincent’s University Hospital, Dublin D04 T6F4, Ireland.
  24. 24Department of Surgery, St. Vincent’s University Hospital, Dublin D04 T6F4, Ireland.
  25. 25Division of Pancreatic Surgery, Department of Surgery, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.
  26. 26Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy.
  27. 27Department of Surgery, Centro Hepatobiliopancreático e Transplantação, Hospital Curry Cabral, Lisbon 1050-099, Portugal.
  28. 28Department of Surgery, University of Colorado, Aurora, CO 80045, USA.
  29. 29Department of Medicine, Stanford University Medical Center, Palo Alto, CA 94304, USA.
  30. 30Department of Hepatobiliary and Pancreatic Surgery, Pathology and Cancer Genomics, National Cancer Center Hospital and National Cancer Center Research Institute, Tokyo 104-0045, Japan.
  31. 31Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan.
  32. 32Department of Gastroenterology and Hepatology, Amsterdam Medical Center, Amsterdam 1017 ZX, Netherlands.
  33. 33Department of Surgery, Johns Hopkins University, Baltimore, MD 21287, USA.
  34. 34Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
  35. 35Department of Biostatistics and Bioinformatics, Johns Hopkins University, Baltimore, MD 21287, USA.
  36. 36Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA.
  1. Corresponding author. Email: bertvog{at}gmail.com (B.V.); amlennon{at}jhmi.edu (A.M.L.); cwolfga2{at}jhmi.edu (C.L.W.); rhruban{at}jhmi.edu (R.H.H.); ctomasetti{at}jhu.edu (C.T.); karchin{at}jhu.edu (R.K.)
  • * These authors contributed equally to this work.

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