Comment on “PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia”

Danilo Perrotti; Anupriya Agarwal; Claire M. Lucas; Goutham Narla; Paolo Neviani; Maria D. Odero; Peter P. Ruvolo; Nicole M. Verrills

doi:10.1126/scitranslmed.aau0416

Technical CommentsCancer

Comment on “PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia”

Danilo Perrotti ¹,²,*,†,
Anupriya Agarwal³,*,
Claire M. Lucas⁴,*,
Goutham Narla⁵,*,
Paolo Neviani⁶,*,
Maria D. Odero⁷,*,
Peter P. Ruvolo⁸,* and
Nicole M. Verrills⁹,*

¹University of Maryland School of Medicine, Baltimore, MD 21201, USA.
²Department of Haematology, Imperial College London, London W12 0HS, UK.
³Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA.
⁴University of Chester Medical School, Chester CH2 1BR, UK.
⁵Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
⁶Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
⁷University of Navarra, Pamplona 31009, Spain.
⁸Department of Leukemia, MD Anderson Cancer Center, Houston, 77054 TX, USA.
⁹School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.

↵†Corresponding author. Email: dperrotti{at}som.umaryland.edu

↵* These authors contributed equally to this work.

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Science Translational Medicine 17 Jul 2019:
Vol. 11, Issue 501, eaau0416
DOI: 10.1126/scitranslmed.aau0416

Danilo Perrotti

University of Maryland School of Medicine, Baltimore, MD 21201, USA.Department of Haematology, Imperial College London, London W12 0HS, UK.

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For correspondence: dperrotti@som.umaryland.edu

Anupriya Agarwal

Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA.

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Claire M. Lucas

University of Chester Medical School, Chester CH2 1BR, UK.

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Goutham Narla

Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

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Paolo Neviani

Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.

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Maria D. Odero

University of Navarra, Pamplona 31009, Spain.

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Peter P. Ruvolo

Department of Leukemia, MD Anderson Cancer Center, Houston, 77054 TX, USA.

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Nicole M. Verrills

School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.

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Abstract

LB100 does not sensitize CML stem cells to tyrosine kinase inhibitor–induced apoptosis.

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Comment on “PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia”

Abstract

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