Research ArticleMYELODYSPLASTIC SYNDROME

A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome

See allHide authors and affiliations

Science Translational Medicine  10 Jul 2019:
Vol. 11, Issue 500, eaav5467
DOI: 10.1126/scitranslmed.aav5467

Article Information

vol. 11 no. 500

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 27, 2018
  • Resubmitted March 19, 2019
  • Accepted for publication June 12, 2019
  • .

Author Information

  1. Sabrina Bondu1,2,3,4,*,
  2. Anne-Sophie Alary1,2,3,4,5,*,
  3. Carine Lefèvre1,2,3,4,6,
  4. Alexandre Houy7,
  5. Grace Jung8,
  6. Thibaud Lefebvre1,6,9,
  7. David Rombaut1,2,3,4,
  8. Ismael Boussaid1,2,3,4,
  9. Abderrahmane Bousta1,2,3,4,
  10. François Guillonneau1,2,3,4,10,
  11. Prunelle Perrier11,
  12. Samar Alsafadi12,
  13. Michel Wassef13,
  14. Raphaël Margueron13,
  15. Alice Rousseau1,2,3,4,
  16. Nathalie Droin14,
  17. Nicolas Cagnard1,15,
  18. Sophie Kaltenbach1,16,
  19. Susann Winter17,
  20. Anne-Sophie Kubasch18,
  21. Didier Bouscary1,2,3,4,19,
  22. Valeria Santini20,
  23. Andrea Toma21,
  24. Mathilde Hunault22,
  25. Aspasia Stamatoullas23,
  26. Emmanuel Gyan24,
  27. Thomas Cluzeau25,
  28. Uwe Platzbecker18,
  29. Lionel Adès1,26,
  30. Hervé Puy1,6,9,
  31. Marc-Henri Stern27,
  32. Zoubida Karim1,6,9,
  33. Patrick Mayeux1,2,3,4,6,10,
  34. Elizabeta Nemeth8,
  35. Sophie Park28,
  36. Tomas Ganz8,
  37. Léon Kautz11,
  38. Olivier Kosmider1,2,3,4,5,6, and
  39. Michaëla Fontenay1,2,3,4,5,6,
  1. 1Université de Paris, Paris 75006, France.
  2. 2Institut Cochin, Département Développement, Reproduction, Cancer, Paris 75014, France.
  3. 3Institut National de la Santé et de la Recherche médicale (INSERM) U1016, Paris 75014, France.
  4. 4Centre National de la Recherche Scientifique (CNRS) Unité Mixte de recherche (UMR) 8104, Paris 75014, France.
  5. 5Service d’hématologie biologique, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Paris Centre–Cochin, Paris 75014, France.
  6. 6Laboratoire d’excellence du Globule Rouge GR-Ex, Paris 75015, France.
  7. 7Institut Curie, PSL Research University, Human Genetics and Oncogenesis, Paris 75005, France.
  8. 8Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  9. 9INSERM, UMR 1149/ERL CNRS 8252, Centre de Recherches sur l'inflammation, Université de Paris, Paris 75018, France.
  10. 10Proteomic platform 3P5, Université de Paris, Paris 75014, France.
  11. 11Institut de Recherche en Santé Digestive (IRSD), Université de Toulouse, INSERM U1220, Institut National de la Recherche Agronomique U1416, Ecole Nationale Vétérinaire de Toulouse, Université Paul Sabatier, Toulouse 31024, France.
  12. 12Institut Curie, PSL Research University, Department of Translational Research, Paris 75005, France.
  13. 13Institut Curie, PSL Research University, INSERM 934/UMR 3215, Genetics and biology of Development, Paris 75005 France.
  14. 14Institut Gustave Roussy, Genomic platform, Villejuif 94805, France.
  15. 15Platform Bioinformatics, Université de Paris, Paris 75015, France.
  16. 16Laboratoire de Génétique, AP-HP, Hôpital Necker, Paris 75015, France.
  17. 17Medical Clinic und Policlinic 1, Technische Universität Dresden, Dresden 01307, Germany.
  18. 18Medical Clinic und Policlinic 1, Hematology and Cellular Therapy, University Hospital, Leipzig 04103, Germany.
  19. 19Service d’Hématologie clinique, AP-HP, Hôpitaux Universitaires Paris Centre–Cochin, Paris 75014, France.
  20. 20MDS unit, Hematology, AOU Careggi, University of Florence, Florence 50134, Italy.
  21. 21Département d’Hématologie, AP-HP, Hôpital Henri-Mondor, Université Paris 12, Créteil 94000, France.
  22. 22Service des Maladies du Sang, Centre hospitalo-universitaire, Angers 49100, France.
  23. 23Département d’hématologie, Centre Henri-Becquerel, Rouen 76038, France.
  24. 24Service d’hématologie et thérapie cellulaire, Centre hospitalo-universitaire, CNRS ERL 7001 LNOx, Université de Tours, Tours 37044, France.
  25. 25Côte d'Azur University, CHU of Nice, Hematology department and INSERM U1065, Mediterranean Center of Molecular Medecine, Nice 06204, France.
  26. 26Service d’Hématologie Senior, AP-HP, Hôpital Saint-Louis, Paris 75010, France.
  27. 27Institut Curie, PSL Research University, INSERM U830, Genetics and biology of cancers, DNA repair and uveal melanoma (D.R.U.M.), Équipe labellisée par la Ligue nationale contre le cancer, Paris 75005, France.
  28. 28Département d’Hématologie, Centre Hospitalier Universitaire, Université de Grenoble Alpes, La Tronche 38700, France.
  1. Corresponding author. Email: michaela.fontenay{at}inserm.fr (M.F.); olivier.kosmider{at}aphp.fr (O.K.)
  • * These authors contributed equally to this work.

Altmetric

Article usage

Article usage: July 2019 to October 2019

AbstractFullPdf
Jul 201940891141414
Aug 20192117283
Sep 20191496247
Oct 2019362119