Research ArticleALLERGY

An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis

See allHide authors and affiliations

Science Translational Medicine  10 Jul 2019:
Vol. 11, Issue 500, eaat1479
DOI: 10.1126/scitranslmed.aat1479

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

A shocking contributor in drug-induced anaphylaxis

Classic anaphylaxis is thought to depend on IgE engagement of Fc receptors on mast cells and basophils, but allergen-specific IgE is not always present. To resolve this conundrum, Jönsson and colleagues studied samples from people that experienced anaphylaxis after neuromuscular-blocking agent administration. They found that drug-specific IgG complexes could trigger neutrophils ex vivo and anaphylactic patients had increased circulating activated neutrophils. Not all of the patients had detectable antidrug IgE. Their results reveal that alternative pathways may be at play and could help develop tests to reduce risk in anesthetic drug administration.

View Full Text