Contents
10 July 2019
Vol 11, Issue 500
Vol 11, Issue 500
Research Articles
- Inhibition of natriuretic peptide receptor 1 reduces itch in mice
Natriuretic peptide receptor 1 inhibition with small molecules has therapeutic effects in mouse models of acute and chronic itch.
- An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis
Co-existence of drug-specific IgE and IgG antibodies aggravates neuromuscular-blocking agent-induced anaphylaxis in humans.
- Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors
We report an active immunization mouse model of autoimmune N-methyl-d-aspartate receptor encephalitis that provides insights into the pathophysiology.
- A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome
A variant erythroferrone contributes to hepcidin modulation and systemic iron accumulation in patients with SF3B1-mutated myelodysplastic syndrome.
Review
- Translational impact of NIH-funded nonhuman primate research in transplantation
NIH-funded transplantation research using nonhuman primates has improved immunosuppressive therapies in human transplant recipients.
Editors' Choice
- From mini-brains to neural networks
Cells dissociated from cerebral organoids self-organize into two-dimensional neuronal networks with relatively advanced functionality.
- A primate resource for autism research
A macaque model of SHANK3 mutation exhibits neurological phenotypes similar to patients with autism and Phelan-McDermid Syndrome.
- Gut microbes prevent marathoners from pooping out
Veillonella atypica within the human gut converts lactate to propionate to improve marathoners’ endurance.
About The Cover
ONLINE COVER Ditch the Itch. This image shows a person suffering from itchy skin. Chronic itch is an irritating sensation that can affect any part of the body and creates an urge to scratch. The neuropeptide NPPB promotes itch by activating natriuretic peptide receptor 1 (NPR1) in spinal cord neurons. To discover potential treatments for itch, Solinski et al. used high-throughput screening to identify NPR1 inhibitors. The small molecule JS-11 emerged as the top hit and was tested in mouse models of acute and chronic itch. Systemic JS-11 administration reduced scratching response without adverse effects, suggesting that targeting NPR1 might be effective for treating itch. [CREDIT: THARAKORN/ISTOCKPHOTO]
