Research ArticleCystic Fibrosis
CFTR-PTEN–dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection
- Sebastián A. Riquelme1,*,
- Carmen Lozano2,*,
- Ahmed M. Moustafa3,*,
- Kalle Liimatta1,
- Kira L. Tomlinson1,
- Clemente Britto4,
- Sara Khanal4,
- Simren K. Gill1,
- Apurva Narechania5,
- Jose M. Azcona-Gutiérrez6,
- Emily DiMango7,
- Yolanda Saénz2,
- Paul Planet3 and
- Alice Prince1,†
- 1Department of Pediatrics, Columbia University, New York, NY 10032, USA.
- 2Area de Microbiología Molecular, Centro de Investigación Biomédica de la Rioja (CIBIR), Microbiología Molecular, Logroño, LG 26006, Spain.
- 3Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
- 4Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
- 5American Museum of Natural History, New York, NY 10024, USA.
- 6Departamento de Diagnóstico Biomédico. Laboratorio de Microbiología, Hospital San Pedro, Logroño, LG 26006, Spain.
- 7Department of Medicine, Columbia University, New York, NY 10032, USA.
- ↵†Corresponding author. Email: asp7{at}columbia.edu
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Science Translational Medicine 03 Jul 2019:
Vol. 11, Issue 499, eaav4634
DOI: 10.1126/scitranslmed.aav4634
