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Research ArticleCancer
Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies
- Roheena Z. Panni1,
- John M. Herndon2,
- Chong Zuo2,
- Samarth Hegde2,
- Graham D. Hogg2,
- Brett L. Knolhoff2,
- Marcus A. Breden2,
- Xiaobo Li3,
- Varintra E. Krisnawan2,
- Samia Q. Khan3,
- Julie K. Schwarz4,5,
- Buck E. Rogers4,5,
- Ryan C. Fields1,4,
- William G. Hawkins1,4,
- Vineet Gupta3,* and
- David G. DeNardo2,4,6,*,†
- 1Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 2Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 3Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
- 4Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 5Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 6Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
- ↵†Corresponding author: ddenardo{at}wustl.edu
↵* These authors contributed equally to this work as senior authors.
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Science Translational Medicine 03 Jul 2019:
Vol. 11, Issue 499, eaau9240
DOI: 10.1126/scitranslmed.aau9240
Vol. 11, Issue 499, eaau9240
DOI: 10.1126/scitranslmed.aau9240
Roheena Z. Panni
Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
John M. Herndon
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Chong Zuo
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Samarth Hegde
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Graham D. Hogg
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Brett L. Knolhoff
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Marcus A. Breden
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xiaobo Li
Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Varintra E. Krisnawan
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Samia Q. Khan
Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Julie K. Schwarz
Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Buck E. Rogers
Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ryan C. Fields
Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
William G. Hawkins
Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Vineet Gupta
Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
David G. DeNardo
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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