PerspectiveVaccines

Design of vaccine efficacy trials during public health emergencies

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Science Translational Medicine  03 Jul 2019:
Vol. 11, Issue 499, eaat0360
DOI: 10.1126/scitranslmed.aat0360

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Abstract

Public health emergencies, such as an Ebola disease outbreak, provide a complex and challenging environment for the evaluation of candidate vaccines. Here, we outline the need for flexible and responsive vaccine trial designs to be used in public health emergencies, and we summarize recommendations for their use in this setting.

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