Research ArticleCancer
Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy
- View ORCID ProfileNoor Momin1,2,
- View ORCID ProfileNaveen K. Mehta1,2,*,
- View ORCID ProfileNitasha R. Bennett1,*,
- View ORCID ProfileLeyuan Ma1,3,*,
- View ORCID ProfileJoseph R. Palmeri1,4,
- View ORCID ProfileMagnolia M. Chinn1,2,
- View ORCID ProfileEmi A. Lutz1,2,
- View ORCID ProfileByong Kang1,2,
- View ORCID ProfileDarrell J. Irvine1,2,3,5,6,
- View ORCID ProfileStefani Spranger1,7 and
- View ORCID ProfileK. Dane Wittrup1,2,4,†
- 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
- 2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
- 3Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
- 4Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
- 5Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
- 6Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
- 7Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
- ↵†Corresponding author. Email: wittrup{at}mit.edu
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Translational Medicine 26 Jun 2019:
Vol. 11, Issue 498, eaaw2614
DOI: 10.1126/scitranslmed.aaw2614
Vol. 11, Issue 498, eaaw2614
DOI: 10.1126/scitranslmed.aaw2614
Noor Momin
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Naveen K. Mehta
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Nitasha R. Bennett
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Leyuan Ma
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
3Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Joseph R. Palmeri
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
4Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Magnolia M. Chinn
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Emi A. Lutz
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Byong Kang
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Darrell J. Irvine
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
3Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
5Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
6Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Stefani Spranger
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
7Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
K. Dane Wittrup
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
4Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
