Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy

Noor Momin; Naveen K. Mehta; Nitasha R. Bennett; Leyuan Ma; Joseph R. Palmeri; Magnolia M. Chinn; Emi A. Lutz; Byong Kang; Darrell J. Irvine; Stefani Spranger; K. Dane Wittrup

doi:10.1126/scitranslmed.aaw2614

Research ArticleCancer

Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy

Noor Momin¹,²,
Naveen K. Mehta¹,²,*,
Nitasha R. Bennett¹,*,
Leyuan Ma¹,³,*,
Joseph R. Palmeri¹,⁴,
Magnolia M. Chinn¹,²,
Emi A. Lutz¹,²,
Byong Kang¹,²,
Darrell J. Irvine¹,²,³,⁵,⁶,
Stefani Spranger¹,⁷ and
K. Dane Wittrup ¹,²,⁴,†

¹Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
²Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
³Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
⁴Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
⁵Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
⁶Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
⁷Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

↵†Corresponding author. Email: wittrup{at}mit.edu

↵* These authors contributed equally to this work.

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Science Translational Medicine 26 Jun 2019:
Vol. 11, Issue 498, eaaw2614
DOI: 10.1126/scitranslmed.aaw2614

Noor Momin

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Naveen K. Mehta

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Nitasha R. Bennett

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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Leyuan Ma

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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Joseph R. Palmeri

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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Magnolia M. Chinn

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Emi A. Lutz

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Byong Kang

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Darrell J. Irvine

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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Stefani Spranger

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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K. Dane Wittrup

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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For correspondence: wittrup@mit.edu

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Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy

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