Research ArticleCancer

Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy

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Science Translational Medicine  26 Jun 2019:
Vol. 11, Issue 498, eaaw2614
DOI: 10.1126/scitranslmed.aaw2614

Article Information

vol. 11 no. 498

PubMed: 
Print ISSN: 
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History: 
  • Received for publication December 3, 2018
  • Resubmitted March 29, 2019
  • Accepted for publication June 4, 2019
  • .

Author Information

  1. Noor Momin1,2,
  2. Naveen K. Mehta1,2,*,
  3. Nitasha R. Bennett1,*,
  4. Leyuan Ma1,3,*,
  5. Joseph R. Palmeri1,4,
  6. Magnolia M. Chinn1,2,
  7. Emi A. Lutz1,2,
  8. Byong Kang1,2,
  9. Darrell J. Irvine1,2,3,5,6,
  10. Stefani Spranger1,7 and
  11. K. Dane Wittrup1,2,4,
  1. 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  2. 2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  3. 3Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  4. 4Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  5. 5Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
  6. 6Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  7. 7Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  1. Corresponding author. Email: wittrup{at}mit.edu
  • * These authors contributed equally to this work.

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Sep 2019177111102