Research ArticleCancer

Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy

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Science Translational Medicine  26 Jun 2019:
Vol. 11, Issue 498, eaaw2614
DOI: 10.1126/scitranslmed.aaw2614

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Keeping it local

Cancer immunotherapy has greatly advanced in recent years, with a variety of promising approaches. Unfortunately, many patients still do not respond to the available therapeutics. Cytokine-based treatments have been proposed in the past but have not caught on because of the severe adverse effects associated with systemic cytokine exposure. To address this problem, Momin et al. fused antitumor cytokines to the collagen-binding protein lumican. Intratumoral injection of the resulting fusion proteins in mouse models of cancer effectively potentiated the effects of other immunotherapies and stimulated systemic antitumor immunity without detectable toxicity.

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