Contents
26 June 2019
Vol 11, Issue 498
Vol 11, Issue 498
Research Articles
- Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy
Collagen-localized cytokines potentiate disparate systemic cancer immunotherapies while minimizing toxicity in many tumor models.
- Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses
Pediatric acute lymphoblastic leukemia elicits a broad, functional, antitumor T cell response, targeting multiple mutations.
- A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice
The T164S mutation in the NS1 protein of dengue virus increases disease severity in mice through complement activation.
- Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer
Antagonism of arginine vasopressin receptor 1a inhibits growth of emergent, established, and bone metastatic castration-resistant prostate cancer.
- Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice
Resolved brain virus infection early in life leaves persisting chemotactic cues that foster brain autoimmunity in adulthood.
Focus
- A decade of digital medicine innovation
The field of digital medicine has matured over the past decade, but validation will require careful randomized, controlled clinical trials.
Editors' Choice
- Sussing out sensitivity to light: How evening light impacts individuals’ circadian systems
Interindividual differences in sensitivity to evening light may present a new component of circadian disruption.
- Deciphering the mechanoreceptor network of human hands
Machine learning based on gloves with tactile sensor arrays helps scientists understand the complex patterns of hand grasping.
- From micrographs to microsatellites in one bold step
Machine learning predicts microsatellite instability from histology.
About The Cover
ONLINE COVER Location, Location, Location. This image depicts the collagen-binding protein lumican (purple) and blood vessels (green) in a cross-section of a mouse melanoma. Momin et al. fused lumican to cytokines and combined these fusion proteins with several types of cancer immunotherapy. This approach localized the therapy to tumors and was effective in reducing tumor growth in multiple mouse models, while avoiding the side effects of systemic therapy. [CREDIT: NOOR MOMIN AND FELICE FRANKEL/MASSACHUSETTS INSTITUTE OF TECHNOLOGY]
