26 June 2019
Vol 11, Issue 498

About The Cover

Cover image expansion

ONLINE COVER Location, Location, Location. This image depicts the collagen-binding protein lumican (purple) and blood vessels (green) in a cross-section of a mouse melanoma. Momin et al. fused lumican to cytokines and combined these fusion proteins with several types of cancer immunotherapy. This approach localized the therapy to tumors and was effective in reducing tumor growth in multiple mouse models, while avoiding the side effects of systemic therapy. [CREDIT: NOOR MOMIN AND FELICE FRANKEL/MASSACHUSETTS INSTITUTE OF TECHNOLOGY]