Editors' ChoiceGene Therapy

Neutralizing antibodies for AAV vectors: The strange case of AAV5

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Science Translational Medicine  19 Jun 2019:
Vol. 11, Issue 497, eaax9567
DOI: 10.1126/scitranslmed.aax9567


A clinical trial on hemophilia B demonstrated efficient liver targeting with AAV5 in the presence of neutralizing antibodies.

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