Research ArticleCancer

Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in diffuse large B cell lymphoma

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Science Translational Medicine  19 Jun 2019:
Vol. 11, Issue 497, eaav5599
DOI: 10.1126/scitranslmed.aav5599

Article Information

vol. 11 no. 497

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History: 
  • Received for publication September 28, 2018
  • Resubmitted January 31, 2019
  • Accepted for publication May 15, 2019
  • .

Author Information

  1. Neeraj Jain1,*,
  2. Keenan Hartert2,*,
  3. Saber Tadros1,2,*,
  4. Warren Fiskus3,
  5. Ondrej Havranek1,,
  6. Man Chun John Ma1,
  7. Alyssa Bouska4,
  8. Tayla Heavican4,
  9. Dhiraj Kumar5,
  10. Qing Deng1,
  11. Dalia Moore2,
  12. Christine Pak6,
  13. Chih Long Liu7,
  14. Andrew J. Gentles8,
  15. Elena Hartmann9,10,
  16. Robert Kridel11,
  17. Karin Ekstrom Smedby12,
  18. Gunnar Juliusson13,
  19. Richard Rosenquist14,
  20. Randy D. Gascoyne15,
  21. Andreas Rosenwald9,10,
  22. Filippo Giancotti5,
  23. Sattva S. Neelapu1,
  24. Jason Westin1,
  25. Julie M. Vose16,
  26. Matthew A. Lunning16,
  27. Timothy Greiner4,
  28. Scott Rodig6,
  29. Javeed Iqbal4,
  30. Ash A. Alizadeh7,
  31. R. Eric Davis1,
  32. Kapil Bhalla3,17 and
  33. Michael R. Green1,17,18,
  1. 1Department of Lymphoma/Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  2. 2Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  3. 3Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  4. 4Department of Pathology and Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  5. 5Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  6. 6Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  7. 7Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
  8. 8Department of Radiology, Stanford University, Stanford, CA 94305, USA.
  9. 9Institute of Pathology, University of Würzburg, Würzburg 97080, Germany.
  10. 10Comprehensive Cancer Center Mainfranken, Wurzburg 97080, Germany.
  11. 11Princess Margaret Cancer Center, University of Toronto, Toronto, ON M5G 2C4, Canada.
  12. 12Department of Medicine, Solna, Clinical Epidemiology Unit, Karolinska Institutet, and Hematology Center, Karolinska University Hospital, Stockholm SE-171 76, Sweden.
  13. 13Department of Laboratory Medicine, Stem Cell Center, Lund University, Lund SE-221 00, Sweden.
  14. 14Department of Molecular Medicine and Surgery, Karolinska Universitetssjukhuset, Stockholm SE-171 76, Sweden.
  15. 15Center for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC V5Z 4E6, Canada.
  16. 16Division of Hematology and Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  17. 17Center for Cancer Epigenetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  18. 18Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  1. Corresponding author. Email: mgreen5{at}mdanderson.org
  • * These authors contributed equally to this work.

  • Present address: BIOCEV, First Faculty of Medicine, Charles University Prague, Prumyslova 595, 252 50 Vestec Czech Republic.

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