Targeting pancreatic islet PTP1B improves islet graft revascularization and transplant outcomes

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Science Translational Medicine  19 Jun 2019:
Vol. 11, Issue 497, eaar6294
DOI: 10.1126/scitranslmed.aar6294

Revascularizing eye-lets

Pancreatic islet transplantation is a potentially promising therapy for type 1 diabetes, but poor revascularization hinders islet long-term viability. Figueiredo et al. studied the role of protein tyrosine phosphatase 1B (PTP1B) in regulating islet vascularization. Islets from PTP1B−/− mice retained more endothelial cells during in vitro culture and restored normoglycemia when transplanted into the anterior chamber of the eye in diabetic mice. Short hairpin RNA knockdown of PTP1B in human islets yielded similar effects. Deletion of PTP1B increased vascular endothelial growth factor A secretion by activating peroxisome proliferator–activated receptor γ coactivator 1α and estrogen-related receptor α signaling. Targeting PTP1B may improve islet transplantation.

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