19 June 2019
Vol 11, Issue 497

About The Cover

Cover image expansion

ONLINE COVER Clearing Out the Cobwebs. Systemic sclerosis (SSc) results in the progressive deposition of collagen fibers in the skin and viscera, as shown in this patient skin explant (type 1 collagen, gold; type 3 collagen, green). Shin et al. identified a constitutively activated enhancer in SSc that promoted fibrosis by locking fibroblasts into expressing TGFB2. The enhancer was epigenetically regulated in part by BRD4. A bromodomain inhibitor promoted the clearance of cutaneous collagen in ex vivo patient skin samples. These findings identify a target for developing new therapies to treat fibrosis in patients with SSc. [CREDIT: SHIN ET AL./SCIENCE TRANSLATIONAL MEDICINE]