Research ArticleCancer
Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy
- View ORCID ProfileChristina Claus1,*,
- Claudia Ferrara1,*,
- Wei Xu1,*,
- Johannes Sam1,
- Sabine Lang1,
- Franziska Uhlenbrock2,
- Rosmarie Albrecht1,
- Sylvia Herter1,
- Ramona Schlenker1,
- Tamara Hüsser1,
- Sarah Diggelmann1,
- John Challier1,
- Ekkehard Mössner1,
- Ralf J. Hosse1,
- Thomas Hofer1,
- Peter Brünker1,
- Catherine Joseph3,
- Jörg Benz3,
- View ORCID ProfilePhilippe Ringler4,
- View ORCID ProfileHenning Stahlberg4,
- Matthias Lauer3,
- Mario Perro1,
- Stanford Chen1,
- Christine Küttel1,
- Preethi L. Bhavani Mohan1,
- Valeria Nicolini1,
- Martina Carola Birk1,
- Amandine Ongaro1,
- Christophe Prince1,
- Reto Gianotti1,
- Gregory Dugan5,
- View ORCID ProfileChristopher T. Whitlow5,
- Kiran Kumar Solingapuram Sai5,
- David L. Caudell5,
- Armando G. Burgos-Rodriguez6,
- View ORCID ProfileJ. Mark Cline5,
- Michael Hettich3,
- Maurizio Ceppi3,
- Anna Maria Giusti3,
- Flavio Crameri3,
- Wouter Driessen3,
- Peter N. Morcos7,
- View ORCID ProfileAnne Freimoser-Grundschober1,
- View ORCID ProfileVictor Levitsky1,
- Maria Amann1,
- Sandra Grau-Richards1,
- Thomas von Hirschheydt8,
- Stella Tournaviti8,
- Michael Mølhøj8,
- Tanja Fauti1,
- Viola Heinzelmann-Schwarz9,
- Volker Teichgräber1,
- Sara Colombetti1,
- Marina Bacac1,
- Alfred Zippelius2,
- View ORCID ProfileChristian Klein1 and
- View ORCID ProfilePablo Umaña1,†
- 1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
- 2University of Basel, Department of Biomedicine, Hebelstrasse 20, 4031 Basel, Switzerland.
- 3Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
- 4University of Basel, Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, Klingelbergstrasse 70, 4056 Basel, Switzerland.
- 5Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
- 6Caribbean Primate Research Center, PO Box 1053, Sabana Seca, Puerto Rico 00952, USA.
- 7Roche Innovation Center New York, pRED, 430 E 29th St, New York, NY 10016, USA;
- 8Roche Innovation Center Munich, pRED, Nonnenwald 2, 82377 Penzberg, Germany.
- 9University Hospital Basel, Gynecological Oncology, Spitalstrasse 21, 4031 Basel, Switzerland.
- ↵†Corresponding author. Email: pablo.umana{at}roche.com
↵* These authors contributed equally to this work.
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Science Translational Medicine 12 Jun 2019:
Vol. 11, Issue 496, eaav5989
DOI: 10.1126/scitranslmed.aav5989
Vol. 11, Issue 496, eaav5989
DOI: 10.1126/scitranslmed.aav5989
Christina Claus
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Claudia Ferrara
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Wei Xu
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Johannes Sam
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Sabine Lang
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Franziska Uhlenbrock
2University of Basel, Department of Biomedicine, Hebelstrasse 20, 4031 Basel, Switzerland.
Rosmarie Albrecht
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Sylvia Herter
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Ramona Schlenker
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Tamara Hüsser
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Sarah Diggelmann
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
John Challier
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Ekkehard Mössner
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Ralf J. Hosse
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Thomas Hofer
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Peter Brünker
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Catherine Joseph
3Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
Jörg Benz
3Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
Philippe Ringler
4University of Basel, Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, Klingelbergstrasse 70, 4056 Basel, Switzerland.
Henning Stahlberg
4University of Basel, Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, Klingelbergstrasse 70, 4056 Basel, Switzerland.
Matthias Lauer
3Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
Mario Perro
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Stanford Chen
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Christine Küttel
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Preethi L. Bhavani Mohan
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Valeria Nicolini
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Martina Carola Birk
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Amandine Ongaro
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Christophe Prince
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Reto Gianotti
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Gregory Dugan
5Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Christopher T. Whitlow
5Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Kiran Kumar Solingapuram Sai
5Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
David L. Caudell
5Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Armando G. Burgos-Rodriguez
6Caribbean Primate Research Center, PO Box 1053, Sabana Seca, Puerto Rico 00952, USA.
J. Mark Cline
5Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Michael Hettich
3Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
Maurizio Ceppi
3Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
Anna Maria Giusti
3Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
Flavio Crameri
3Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
Wouter Driessen
3Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
Peter N. Morcos
7Roche Innovation Center New York, pRED, 430 E 29th St, New York, NY 10016, USA;
Anne Freimoser-Grundschober
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Victor Levitsky
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Maria Amann
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Sandra Grau-Richards
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Thomas von Hirschheydt
8Roche Innovation Center Munich, pRED, Nonnenwald 2, 82377 Penzberg, Germany.
Stella Tournaviti
8Roche Innovation Center Munich, pRED, Nonnenwald 2, 82377 Penzberg, Germany.
Michael Mølhøj
8Roche Innovation Center Munich, pRED, Nonnenwald 2, 82377 Penzberg, Germany.
Tanja Fauti
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Viola Heinzelmann-Schwarz
9University Hospital Basel, Gynecological Oncology, Spitalstrasse 21, 4031 Basel, Switzerland.
Volker Teichgräber
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Sara Colombetti
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Marina Bacac
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Alfred Zippelius
2University of Basel, Department of Biomedicine, Hebelstrasse 20, 4031 Basel, Switzerland.
Christian Klein
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
Pablo Umaña
1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.