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Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

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Science Translational Medicine  12 Jun 2019:
Vol. 11, Issue 496, eaav5989
DOI: 10.1126/scitranslmed.aav5989

Article Information

vol. 11 no. 496

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 8, 2018
  • Accepted for publication May 16, 2019
  • .

Author Information

  1. Christina Claus1,*,
  2. Claudia Ferrara1,*,
  3. Wei Xu1,*,
  4. Johannes Sam1,
  5. Sabine Lang1,
  6. Franziska Uhlenbrock2,
  7. Rosmarie Albrecht1,
  8. Sylvia Herter1,
  9. Ramona Schlenker1,
  10. Tamara Hüsser1,
  11. Sarah Diggelmann1,
  12. John Challier1,
  13. Ekkehard Mössner1,
  14. Ralf J. Hosse1,
  15. Thomas Hofer1,
  16. Peter Brünker1,
  17. Catherine Joseph3,
  18. Jörg Benz3,
  19. Philippe Ringler4,
  20. Henning Stahlberg4,
  21. Matthias Lauer3,
  22. Mario Perro1,
  23. Stanford Chen1,
  24. Christine Küttel1,
  25. Preethi L. Bhavani Mohan1,
  26. Valeria Nicolini1,
  27. Martina Carola Birk1,
  28. Amandine Ongaro1,
  29. Christophe Prince1,
  30. Reto Gianotti1,
  31. Gregory Dugan5,
  32. Christopher T. Whitlow5,
  33. Kiran Kumar Solingapuram Sai5,
  34. David L. Caudell5,
  35. Armando G. Burgos-Rodriguez6,
  36. J. Mark Cline5,
  37. Michael Hettich3,
  38. Maurizio Ceppi3,
  39. Anna Maria Giusti3,
  40. Flavio Crameri3,
  41. Wouter Driessen3,
  42. Peter N. Morcos7,
  43. Anne Freimoser-Grundschober1,
  44. Victor Levitsky1,
  45. Maria Amann1,
  46. Sandra Grau-Richards1,
  47. Thomas von Hirschheydt8,
  48. Stella Tournaviti8,
  49. Michael Mølhøj8,
  50. Tanja Fauti1,
  51. Viola Heinzelmann-Schwarz9,
  52. Volker Teichgräber1,
  53. Sara Colombetti1,
  54. Marina Bacac1,
  55. Alfred Zippelius2,
  56. Christian Klein1 and
  57. Pablo Umaña1,
  1. 1Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED), Wagistrasse 10, 8952 Schlieren, Switzerland.
  2. 2University of Basel, Department of Biomedicine, Hebelstrasse 20, 4031 Basel, Switzerland.
  3. 3Roche Innovation Center Basel, pRED, Grenzacherstrasse 124, 4070 Basel, Switzerland.
  4. 4University of Basel, Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, Klingelbergstrasse 70, 4056 Basel, Switzerland.
  5. 5Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
  6. 6Caribbean Primate Research Center, PO Box 1053, Sabana Seca, Puerto Rico 00952, USA.
  7. 7Roche Innovation Center New York, pRED, 430 E 29th St, New York, NY 10016, USA;
  8. 8Roche Innovation Center Munich, pRED, Nonnenwald 2, 82377 Penzberg, Germany.
  9. 9University Hospital Basel, Gynecological Oncology, Spitalstrasse 21, 4031 Basel, Switzerland.
  1. Corresponding author. Email: pablo.umana{at}roche.com
  • * These authors contributed equally to this work.

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