Research ArticleLIVER FIBROSIS

Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

See allHide authors and affiliations

Science Translational Medicine  12 Jun 2019:
Vol. 11, Issue 496, eaat9284
DOI: 10.1126/scitranslmed.aat9284

Article Information

vol. 11 no. 496

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 24, 2018
  • Accepted for publication May 14, 2019
  • .

Author Information

  1. Yoon Mee Yang1,2,
  2. Mazen Noureddin1,3,*,
  3. Cheng Liu4,*,
  4. Koichiro Ohashi1,
  5. So Yeon Kim1,
  6. Divya Ramnath5,
  7. Elizabeth E. Powell6,7,
  8. Matthew J. Sweet5,
  9. Yoon Seok Roh1,8,
  10. I-Fang Hsin1,
  11. Nan Deng9,
  12. Zhenqiu Liu9,
  13. Jiurong Liang1,10,11,
  14. Edward Mena12,
  15. Daniel Shouhed13,
  16. Robert F. Schwabe14,
  17. Dianhua Jiang1,10,11,
  18. Shelly C. Lu1,
  19. Paul W. Noble1,10 and
  20. Ekihiro Seki1,11,
  1. 1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  2. 2College of Pharmacy, Kangwon National University, Chuncheon 24341, South Korea.
  3. 3Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  4. 4Department of Infectious Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.
  5. 5Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, Queensland 4072, Australia.
  6. 6Centre for Liver Disease Research, University of Queensland, Brisbane, Queensland, Australia.
  7. 7Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.
  8. 8Department of Pharmacy, Chungbuk National University College of Pharmacy, Cheongju, Chungbuk 28160, South Korea.
  9. 9Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  10. 10Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  11. 11Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  12. 12California Liver Research Institute, Pasadena, CA 91105, USA.
  13. 13Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  14. 14Department of Medicine, Columbia University, New York, NY 10032, USA.
  1. Corresponding author. Email: ekihiro.seki{at}cshs.org
  • * These authors contributed equally to this work.

Altmetric

Article usage

Article usage: June 2019 to November 2019

AbstractFullPdf
Jun 201946851077483
Jul 2019426219167
Aug 201923810183
Sep 20191419356
Oct 20191256770
Nov 2019292716