A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis

See allHide authors and affiliations

Science Translational Medicine  12 Jun 2019:
Vol. 11, Issue 496, eaar3558
DOI: 10.1126/scitranslmed.aar3558

Article Information

vol. 11 no. 496

Print ISSN: 
Online ISSN: 
  • Received for publication November 2, 2017
  • Resubmitted August 13, 2018
  • Accepted for publication May 14, 2019
  • .

Author Information

  1. M. Jaeger1,2,*,
  2. M. Pinelli3,4,*,
  3. M. Borghi5,
  4. C. Constantini5,
  5. M. Dindo5,
  6. L. van Emst1,
  7. M. Puccetti5,
  8. M. Pariano5,
  9. I. Ricaño-Ponce6,
  10. C. Büll7,
  11. M. S. Gresnigt1,2,8,
  12. X. Wang1,9,
  13. J. Gutierrez Achury6,
  14. C. W. M. Jacobs1,
  15. N. Xu10,
  16. M. Oosting1,
  17. P. Arts4,
  18. L. A. B. Joosten1,
  19. F. L. van de Veerdonk1,
  20. J. A. Veltman4,11,
  21. J. ten Oever1,
  22. B. J. Kullberg1,
  23. M. Feng10,
  24. G. J. Adema7,
  25. C. Wijmenga6,
  26. V. Kumar6,
  27. J. Sobel12,
  28. C. Gilissen4,
  29. L. Romani5 and
  30. M. G. Netea1,13,
  1. 1Department of Internal Medicine and Radboud Centre for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, 6525GA, Netherlands.
  2. 2Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen Medical Center (Radboudumc), Nijmegen, 6525GA, Netherlands.
  3. 3Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Naples, 80078, Italy.
  4. 4Department of Human Genetics, Donders Center for Neuroscience, Radboud University Medical Center, Nijmegen, 6525HR, Netherlands.
  5. 5Department of Experimental Medicine, University of Perugia, Polo Unico Sant’Andrea delle Fratte, Perugia, 06123, Italy.
  6. 6University of Groningen, University Medical Centre Groningen, Department of Genetics, Groningen, 9713GZ, Netherlands.
  7. 7Department of Radiation Oncology, Radiotherapy & OncoImmunology Laboratory, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 32, Nijmegen, 6525GA, Netherlands.
  8. 8Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology–Hans Knöll Institute, Beutenbergstraße 11a, Jena, 07745, Germany.
  9. 9College of Computer, Qinghai Normal University, 810008 Xining, China.
  10. 10BGI-Shenzhen, Shenzhen 518083, China.
  11. 11Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, 6229HX, Netherlands.
  12. 12Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201, USA.
  13. 13Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, 200349,
  14. Romania.
  1. Corresponding author. Email: mihai.netea{at}
  • * These authors contributed equally to this work as co-first authors.


Article usage

Article usage: June 2019 to November 2019

Jun 20194426932242
Jul 20192009365
Aug 20191324641
Sep 20191414930
Oct 20191335035
Nov 20191173716