12 June 2019
Vol 11, Issue 496

About The Cover

Cover image expansion

ONLINE COVER Tumor Cells in the Crosshairs. This image depicts a laser beam similar to those used to detect circulating melanoma cells, seen as a bright spot against the background of small blood vessels in a mouse. A photoacoustic imaging device designed by Galanzha et al. takes advantage of melanoma cells' distinctive pigmentation to detect them directly in human patients' circulation. Counting the number of circulating melanoma cells can help assess the risk of metastasis, and cells could be destroyed with a laser in situ as a potential therapy. [CREDIT: E. GALANZHA/ UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES]