12 June 2019
Vol 11, Issue 496
  • Research Articles

    • In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma

      Noninvasive label-free photoacoustic detection of circulating tumor cells was demonstrated directly in the bloodstream of patients with melanoma.

    • The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

      Tryptophan-derived metabolites from the gut microbiota control miR-181 expression in mouse white adipocytes to regulate metabolism and inflammation.

    • Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

      Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target.

    • A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis

      SIGLEC15 is a component of the host immune response against Candida albicans and is dysregulated in patients with recurrent vulvovaginal candidiasis.

    • Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

      Tumor-targeted 4-1BB agonists provide costimulation as combination partners for cancer immunotherapies in solid and hematological tumors.

  • Focus

  • Editors' Choice

About The Cover

Cover image expansion

ONLINE COVER Tumor Cells in the Crosshairs. This image depicts a laser beam similar to those used to detect circulating melanoma cells, seen as a bright spot against the background of small blood vessels in a mouse. A photoacoustic imaging device designed by Galanzha et al. takes advantage of melanoma cells' distinctive pigmentation to detect them directly in human patients' circulation. Counting the number of circulating melanoma cells can help assess the risk of metastasis, and cells could be destroyed with a laser in situ as a potential therapy. [CREDIT: E. GALANZHA/ UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES]