Research ArticleAutoimmunity

Lymphocyte-driven regional immunopathology in pneumonitis caused by impaired central immune tolerance

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Science Translational Medicine  05 Jun 2019:
Vol. 11, Issue 495, eaav5597
DOI: 10.1126/scitranslmed.aav5597

Article Information

vol. 11 no. 495

PubMed: 
Print ISSN: 
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History: 
  • Received for publication September 28, 2018
  • Accepted for publication April 5, 2019
  • .

Author Information

  1. Elise M. N. Ferré1,
  2. Timothy J. Break1,*,
  3. Peter D. Burbelo2,*,
  4. Michael Allgäuer3,4,
  5. David E. Kleiner3,
  6. Dakai Jin5,
  7. Ziyue Xu5,
  8. Les R. Folio5,
  9. Daniel J. Mollura5,
  10. Muthulekha Swamydas1,
  11. Wenjuan Gu6,
  12. Sally Hunsberger6,
  13. Chyi-Chia R. Lee3,
  14. Anamaria Bondici1,
  15. Kevin W. Hoffman7,
  16. Jean K. Lim7,
  17. Kerry Dobbs8,
  18. Julie E. Niemela9,
  19. Thomas A. Fleisher9,
  20. Amy P. Hsu10,
  21. Laquita N. Snow1,
  22. Dirk N. Darnell1,
  23. Samar Ojaimi11,12,
  24. Megan A. Cooper13,
  25. Martin Bozzola14,
  26. Gary I. Kleiner15,
  27. Juan C. Martinez16,
  28. Robin R. Deterding17,
  29. Douglas B. Kuhns18,
  30. Theo Heller19,
  31. Karen K. Winer20,
  32. Arun Rajan21,
  33. Steven M. Holland10,
  34. Luigi D. Notarangelo8,
  35. Kevin P. Fennelly22,
  36. Kenneth N. Olivier22 and
  37. Michail S. Lionakis1,
  1. 1Fungal Pathogenesis Section, LCIM, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  2. 2Dental Clinical Research Core, National Institute of Dental and Craniofacial Research (NIDCR), NIH, Bethesda, MD 20892, USA.
  3. 3Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.
  4. 4Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  5. 5Radiology and Imaging Sciences, NIH Clinical Center (CC), NIH, Bethesda, MD 20892, USA.
  6. 6Biostatistics Research Branch, Division of Clinical Research (DCR), NIAID, NIH, Bethesda, MD 20892, USA.
  7. 7Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  8. 8Immune Deficiency Genetics Section, LCIM, NIAID, NIH, Bethesda, MD 20892, USA.
  9. 9Immunology Service, Department of Laboratory Medicine (DLM), NIH CC, NIH, Bethesda, MD 20892, USA.
  10. 10Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, MD 20892, USA.
  11. 11Department of Infectious Diseases, Monash Health, Melbourne, VIC 3800, Australia.
  12. 12Centre for Inflammatory Diseases, Monash University, Melbourne, VIC 3800, Australia.
  13. 13Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  14. 14Department of Pediatrics, British Hospital, Perdriel 74, CABA—Buenos Aires, Argentina.
  15. 15University of Miami Department of Pediatrics, Miami, FL 33136, USA.
  16. 16Cystic Fibrosis, Pulmonary, and Sleep Division, Joe DiMaggio Children’s Hospital, Hollywood, FL 33021, USA.
  17. 17Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado, Aurora, CO 80045, USA.
  18. 18Neutrophil Monitoring Laboratory, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA.
  19. 19Translational Hepatology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
  20. 20Pediatric Growth and Nutrition Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD 20892, USA.
  21. 21Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.
  22. 22Laboratory of Chronic Airway Infection, Pulmonary Branch, National Heart, Lung, and Blood Institute (NHLBI), Bethesda, MD 20892, USA.
  1. Corresponding author. Email: lionakism{at}mail.nih.gov
  • * These authors contributed equally to this work.

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