Research ArticleFibrosis

Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis

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Science Translational Medicine  05 Jun 2019:
Vol. 11, Issue 495, eaav5341
DOI: 10.1126/scitranslmed.aav5341

Preventing peritoneal fibrosis

Peritoneal dialysis is used to treat patients with end-stage renal disease, but many of these patients develop peritoneal fibrosis that limits treatment efficacy. Si et al. studied cells from patients undergoing peritoneal dialysis and used a mouse model to understand the mechanism underlying progression of peritoneal fibrosis. They found that transforming growth factor β1 stimulated hyperglycolysis in mesothelial cells, contributing to a mesothelial-to-mesenchymal transition phenotype and peritoneal fibrosis. Manipulating the expression of three microRNAs using adeno-associated viruses could inhibit fibrosis in the mouse model, suggesting that correcting the altered metabolic state in mesothelial cells could be therapeutic for peritoneal fibrosis.

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