Research ArticleParkinson’s Disease
A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology
- Juan A. Gerez1,2,*,
- Natalia C. Prymaczok1,2,
- View ORCID ProfileEdward Rockenstein3,
- Uli S. Herrmann4,
- Petra Schwarz4,
- Anthony Adame3,
- Radoslav I. Enchev1,†,
- Thibault Courtheoux1,
- View ORCID ProfilePaul J. Boersema1,‡,
- Roland Riek2,
- View ORCID ProfileMatthias Peter1,
- View ORCID ProfileAdriano Aguzzi4,
- Eliezer Masliah3§ and
- Paola Picotti1,5
- 1Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
- 2Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.
- 3Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.
- 4Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland.
- 5Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
- ↵*Corresponding author. Email: juan.gerez{at}phys.chem.ethz.ch
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Science Translational Medicine 05 Jun 2019:
Vol. 11, Issue 495, eaau6722
DOI: 10.1126/scitranslmed.aau6722
Vol. 11, Issue 495, eaau6722
DOI: 10.1126/scitranslmed.aau6722
Juan A. Gerez
1Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
2Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.
Natalia C. Prymaczok
1Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
2Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.
Edward Rockenstein
3Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.
Uli S. Herrmann
4Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland.
Petra Schwarz
4Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland.
Anthony Adame
3Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.
Radoslav I. Enchev
1Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
Thibault Courtheoux
1Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
Paul J. Boersema
1Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
Roland Riek
2Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.
Matthias Peter
1Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
Adriano Aguzzi
4Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland.
Eliezer Masliah
3Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.
Paola Picotti
1Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
5Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
