Research ArticleParkinson’s Disease

A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology

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Science Translational Medicine  05 Jun 2019:
Vol. 11, Issue 495, eaau6722
DOI: 10.1126/scitranslmed.aau6722

Article Information

vol. 11 no. 495

Print ISSN: 
Online ISSN: 
  • Received for publication July 4, 2018
  • Resubmitted November 16, 2018
  • Accepted for publication May 8, 2019
  • .

Author Information

  1. Juan A. Gerez1,2,*,
  2. Natalia C. Prymaczok1,2,
  3. Edward Rockenstein3,
  4. Uli S. Herrmann4,
  5. Petra Schwarz4,
  6. Anthony Adame3,
  7. Radoslav I. Enchev1,,
  8. Thibault Courtheoux1,
  9. Paul J. Boersema1,,
  10. Roland Riek2,
  11. Matthias Peter1,
  12. Adriano Aguzzi4,
  13. Eliezer Masliah3§ and
  14. Paola Picotti1,5
  1. 1Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
  2. 2Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.
  3. 3Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.
  4. 4Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland.
  5. 5Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
  1. *Corresponding author. Email: juan.gerez{at}
  • Present address: The Francis Crick Institute, Visual Biochemistry Laboratory, London, UK.

  • Present address: Novartis Pharma AG, Basel, Switzerland.

  • § Present address: Laboratory of Neurogenetics and Division of Neuroscience, National Institute on Aging, NIH, Bethesda, MD, USA.


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Jul 2019270165114
Aug 20191658686
Sep 20191638775
Oct 2019503226