05 June 2019
Vol 11, Issue 495

About The Cover

Cover image expansion

ONLINE COVER Knocking Out Pneumonitis. Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) experience a variety of autoimmune symptoms and clinical complications. Ferré et al. discovered that almost half of a large cohort of patients with APECED suffered from undiagnosed pneumonitis. Treating five patients with lymphocyte-targeted therapy resolved respiratory symptoms and cellular infiltration (shown here in green) in the lungs and airways. Clinicians caring for patients with APECED should screen for pneumonitis, which could potentially be treated with immunomodulatory strategies. [CREDIT: FERRÉ ET AL./SCIENCE TRANSLATIONAL MEDICINE]