Contents
05 June 2019
Vol 11, Issue 495
Vol 11, Issue 495
Review
- Supercharging adoptive T cell therapy to overcome solid tumor–induced immunosuppression
Immune checkpoints can be targeted using exogenous reagents or via genetic modification to enhance the efficacy of adoptive T cell therapy.
Research Articles
- Lymphocyte-driven regional immunopathology in pneumonitis caused by impaired central immune tolerance
AIRE deficiency causes a characteristic pattern of pulmonary immunopathology that is responsive to T and B lymphocyte–directed immunomodulation.
- Naturally acquired immunity against immature Plasmodium falciparum gametocytes
Naturally acquired immune responses target infected red blood cell surface antigens of immature malaria transmission stages.
- Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis
Peritoneal fibrosis due to hyperglycolysis in mesothelial cells can be prevented by a triad of microRNAs.
- Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration
Mechanical loading regulates mesenchymal condensation–mediated endochondral bone regeneration.
- A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology
An iron-regulated ubiquitin ligase targets exogenous α-synuclein for degradation and counteracts Lewy body–like pathology in preclinical models.
Editors' Choice
- When fat cells are beige, future is brite
Breast milk lipid mediators sustain brite fat development in infants, which may reduce their risk of future obesity.
- Promoting resilience after childhood adversity
Engaging prefrontal control regions during reappraisal promotes resilience to depression after childhood maltreatment.
- Patching up a wounded heart
A bioresorbable patch provides structural support and a conduit for minimally invasive stem cell delivery to the heart after myocardial infarction.
- A bit too much Olig2 in Down’s syndrome
Overproduction of the Olig2 gene responsible for cerebral cortex neurotransmission may explain cognitive impairment in Down’s syndrome.
About The Cover
ONLINE COVER Knocking Out Pneumonitis. Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) experience a variety of autoimmune symptoms and clinical complications. Ferré et al. discovered that almost half of a large cohort of patients with APECED suffered from undiagnosed pneumonitis. Treating five patients with lymphocyte-targeted therapy resolved respiratory symptoms and cellular infiltration (shown here in green) in the lungs and airways. Clinicians caring for patients with APECED should screen for pneumonitis, which could potentially be treated with immunomodulatory strategies. [CREDIT: FERRÉ ET AL./SCIENCE TRANSLATIONAL MEDICINE]