Editors' ChoiceCancer

PARP inhibitors need an extra STING for therapeutic efficacy

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Science Translational Medicine  29 May 2019:
Vol. 11, Issue 494, eaax9557
DOI: 10.1126/scitranslmed.aax9557


PARP inhibitors require the recruitment of CD8+ T cells through STING-cGAS signaling to maximize tumor regression.

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