29 May 2019
Vol 11, Issue 494

About The Cover

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ONLINE COVER Bad to the Bone. Patients with multiple myeloma, a cancer that inhabits the bone marrow, can suffer from persistent bone lesions even when the cancer is in remission. To understand underlying mechanisms, Liu et al. examined adipocytes, which were prominent in patient bone marrow. Media from cultured patient adipocytes promoted osteoclast differentiation (as shown here), which contributed to lesions. In a mouse model, manipulating adipocyte activity decreased osteoclastogenesis and increased bone healing after multiple myeloma clearance. This adipocyte-osteoclast axis could potentially be interrupted to bring relief to patients with multiple myeloma. [CREDIT: LIU ET AL./SCIENCE TRANSLATIONAL MEDICINE]