Contents
29 May 2019
Vol 11, Issue 494
Vol 11, Issue 494
Research Articles
- Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease
Marrow adipocytes reprogrammed by myeloma cells induce bone lesions.
- Accurate needle-free assessment of myocardial oxygenation for ischemic heart disease in canines using magnetic resonance imaging
Cardiac magnetic resonance imaging with repeat hypercapnia accurately detects myocardial oxygenation changes in a dog model of ischemic heart disease.
- Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition
Selective inhibition of γ-secretase complexes targets T-ALL without the dose-limiting side effects of complete γ-secretase inhibition.
- Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome
Brief, early treatments with lovastatin provide long-lasting rescue of associative memory deficits in a rat model of Fragile X.
Report
- Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge
Treatment of African green monkeys with remdesivir (GS-5734) 24 hours after lethal Nipah virus challenge resulted in 100% survival.
Focus
- Depicting brighter possibilities for treating blindness
Advances in preclinical research are now being translated into innovative clinical solutions for blindness.
Editors' Choice
- Resisting resistance: Homing in on better immunotherapy responses
In mouse tumor models, the CXCR3-CXCL9 chemokine system mediates sensitivity to PD-1 blockade and could be exploited to enhance responsiveness to checkpoint inhibitors.
- PARP inhibitors need an extra STING for therapeutic efficacy
PARP inhibitors require the recruitment of CD8+ T cells through STING-cGAS signaling to maximize tumor regression.
- A breath of fresh air for donor lungs
Donor lungs damaged by gastric aspiration can be regenerated to meet transplantation criteria by an interventional cross circulation platform.
About The Cover
ONLINE COVER Bad to the Bone. Patients with multiple myeloma, a cancer that inhabits the bone marrow, can suffer from persistent bone lesions even when the cancer is in remission. To understand underlying mechanisms, Liu et al. examined adipocytes, which were prominent in patient bone marrow. Media from cultured patient adipocytes promoted osteoclast differentiation (as shown here), which contributed to lesions. In a mouse model, manipulating adipocyte activity decreased osteoclastogenesis and increased bone healing after multiple myeloma clearance. This adipocyte-osteoclast axis could potentially be interrupted to bring relief to patients with multiple myeloma. [CREDIT: LIU ET AL./SCIENCE TRANSLATIONAL MEDICINE]