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Research ArticleGene Therapy
Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates
- View ORCID ProfileMichela Milani1,2,*,
- View ORCID ProfileAndrea Annoni1,*,
- Federica Moalli3,
- Tongyao Liu4,
- View ORCID ProfileDaniela Cesana1,
- View ORCID ProfileAndrea Calabria1,
- Sara Bartolaccini1,
- Mauro Biffi1,
- Fabio Russo1,
- Ilaria Visigalli1,
- View ORCID ProfileAndrea Raimondi3,
- Susannah Patarroyo-White4,
- Douglas Drager4,
- View ORCID ProfilePatrizia Cristofori1,5,
- View ORCID ProfileEduard Ayuso6,
- Eugenio Montini1,
- View ORCID ProfileRobert Peters4,
- View ORCID ProfileMatteo Iannacone3,
- View ORCID ProfileAlessio Cantore1,2,†,‡ and
- View ORCID ProfileLuigi Naldini1,2,†,‡
- 1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
- 2Vita-Salute San Raffaele University, 20132 Milan, Italy.
- 3IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
- 4Bioverativ, Waltham, MA 02451, USA.
- 5GlaxoSmithKline R&D UK, Ware SG12 0DP, UK.
- 6INSERM UMR1089, University of Nantes, CHU de Nantes, 44093 Nantes, France.
- ↵†Corresponding author. Email: cantore.alessio{at}hsr.it (A. Cantore); naldini.luigi{at}hsr.it (L.N.)
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Science Translational Medicine 22 May 2019:
Vol. 11, Issue 493, eaav7325
DOI: 10.1126/scitranslmed.aav7325
Vol. 11, Issue 493, eaav7325
DOI: 10.1126/scitranslmed.aav7325
Michela Milani
1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
2Vita-Salute San Raffaele University, 20132 Milan, Italy.
Andrea Annoni
1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Federica Moalli
3IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Tongyao Liu
4Bioverativ, Waltham, MA 02451, USA.
Daniela Cesana
1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Andrea Calabria
1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Sara Bartolaccini
1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Mauro Biffi
1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Fabio Russo
1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Ilaria Visigalli
1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Andrea Raimondi
3IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Susannah Patarroyo-White
4Bioverativ, Waltham, MA 02451, USA.
Douglas Drager
4Bioverativ, Waltham, MA 02451, USA.
Patrizia Cristofori
1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
5GlaxoSmithKline R&D UK, Ware SG12 0DP, UK.
Eduard Ayuso
6INSERM UMR1089, University of Nantes, CHU de Nantes, 44093 Nantes, France.
Eugenio Montini
1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Robert Peters
4Bioverativ, Waltham, MA 02451, USA.
Matteo Iannacone
3IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Alessio Cantore
1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
2Vita-Salute San Raffaele University, 20132 Milan, Italy.
Luigi Naldini
1San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
2Vita-Salute San Raffaele University, 20132 Milan, Italy.
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