Research ArticleCELL THERAPY

Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium

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Science Translational Medicine  22 May 2019:
Vol. 11, Issue 493, eaau1168
DOI: 10.1126/scitranslmed.aau1168

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Tracking therapeutic effects

Stem and progenitor cells are being pursued for a number of regenerative medicine applications; however, tracking cells after transplant and determining therapeutic efficacy can be challenging. Saha et al. isolated exosomes from blood to monitor human cardiosphere-derived cells (CDCs) and cardiac progenitor cells (CPCs) transplanted into rat hearts after myocardial infarction. They found that they could purify CDC/CPC-derived exosomes based on major histocompatibility complex mismatch and that the exosomes contained microRNAs associated with myocardial recovery. Exosomes produced from CPCs and CDCs in culture differed in contents from exosomes produced by transplanted cells in vivo. This study suggests that circulating exosomes can be used to noninvasively monitor transplanted cells.

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